Temporal trends in mortality from diverticular disease of the intestine with septicemia stratified by demographics: a retrospective study

Vishakha; Supreeth Ramu Sunku; Swathi Dasineni

doi:10.18203/2319-2003.ijbcp20263779

Authors

Vishakha Dr. D Y Patil Medical College and Research Hospital, Pune, Maharashtra, India
Supreeth Ramu Sunku Department of Nephrology, NU Hospitals, Padmanabhanagar, Bangalore, Karnataka, India
Swathi Dasineni Ivano Frankivsk National Medical University, Ukraine

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20263779

Keywords:

Diverticular disease of intestine, Septicemia, Age-related mortality rate, Retrospective study, CDC MCD

Abstract

Background: Diverticular disease of the intestine is a major cause of mortality, and its association with septicemia remains underexplored. Understanding this relationship is essential to identify high-risk population and develop targeted public health interventions. The aim of the study is to analyze mortality trends and demographic disparities in diverticular disease of intestine with septicemia as a contributing cause using the CDC multiple causes of Death (MCD) database from 1999-2020.

Methods: A retrospective observational study was conducted using CDC MCD database to assess mortality trends in individuals aged 25 years and older in the United States From 1999-2000. The study included deaths where diverticular disease of intestine (ICD - 10: K57) was listed as the underlying cause and septicemia (ICD-10:A44) as a contributing cause. Data were analyzed by age, gender, race, geographic region, and place of death. Age- related mortality rates (AAMR) and annual percentage change (APC) were calculated.

Results: A total of 67310 Deaths were recorded. The AAMR for diverticular disease of intestine showed increase over time (APC). The highest mortality was observed in females, whites and temporal trends showed increase with disparities noted across demographic and geographic factors.

Conclusions: This study highlights significant mortality trends increasing in diverticular disease of intestine with septicemia, with disparities by gender, age and location. Findings underscore the need for targeted prevention strategies and improved healthcare success.

References

Piscopo N, Ellul P. Diverticular disease: a review on pathophysiology and recent evidence. Ulster Med J. 2020;89(2):83–8.

Brown RF, Lopez K, Smith CB, Charles A. Diverticulitis: a review. JAMA. 2025;334(13):1180–91. doi:10.1001/jama.2025.10234.

Bailey J, Dattani S, Jennings A. Diverticular disease: rapid evidence review. Am Fam Physician. 2022;106(2):150–6.

Williams S, Bjarnason I, Hayee B, Haji A. Diverticular disease: update on pathophysiology, classification and management. Frontline Gastroenterol. 2024;15(1):50–8.

Wan D, Krisko T. Diverticulosis, diverticulitis, and diverticular bleeding. Clin Geriatr Med. 2021;37(1):141–54.

Staines JM, Subramaniyam SS, Jaipal P, Gunasekaran S, Ponnusamy M. An overview of diverticular pathophysiology and its treatment. World J Biol Pharm Health Sci. 2022;12(2):140–55.

Wilkins T, Baird C, Pearson AN, Schade RR. Diverticular bleeding. Am Fam Physician. 2009;80(9):977–83.

Cespedes M, Dones-Rodriguez A, Torres-Gonzalez K. Septic phlebitis: a dangerous complication of diverticulitis. Am J Gastroenterol. 2015;110(Suppl):S125.

Centers for Disease Control and Prevention, National Center for Health Statistics. Multiple cause of death, 1999–2020. CDC WONDER. 2023. Available from: https://wonder.cdc.gov/ Accessed on 14 August 2026.

Deoghare S. Virtual research designs and IRB requirements: clarifying what truly needs ethics approval. Minerva Med. 2026;117(2):96-7.

Ingram DD, Franco SJ. 2013 NCHS urban-rural classification scheme for counties. Vital Health Stat 2. 2014;(166):1–73.

National Center for Health Statistics. Underlying cause of death, 1999–2020: data definitions—place of death. Atlanta: Centers for Disease Control and Prevention. Available from: https://wonder.cdc.gov/wonder/help/ucd.html Accessed on 14 August 2026.

Sorlie PD, Thom TJ, Manolio T, et al. Age-adjusted death rates: consequences of the year 2000 standard. Ann Epidemiol. 1999;9:93–100.

National Cancer Institute. Joinpoint Regression Program, version 5.0.2. Statistical Methodology and Applications Branch, Surveillance Research Program; 2023. Available from: https://surveillance.cancer.gov/joinpoint Accessed on 14 August 2026.

Bharucha AE, Parthasarathy G, Ditah I, et al. Temporal trends in the incidence and natural history of diverticulitis: a population-based study. Am J Gastroenterol. 2015;110(11):1589–96.

Cameron R, Walker MM, Thuresson M, et al. Mortality risk increased in colonic diverticular disease: a nationwide cohort study. Ann Epidemiol. 2022;76:39–49.

Cameron RA, Jones MP, Eslick GD, Talley NJ. Colonic diverticulosis and uncomplicated diverticulitis are associated with a lower not higher risk of mortality when confounding factors are held constant. J Gastroenterol Hepatol. 2025;40(5):1221–9.

Sell NM, Perez NP, Stafford CE, et al. Are there variations in mortality from diverticular disease by sex? Dis Colon Rectum. 2020;63(9):1285–92.

Hunt CW, Chaturvedi R, Brown L, et al. Diverticular disease epidemiology: rising rates of diverticular disease mortality across developing nations. Dis Colon Rectum. 2021;64(1):81–90.

Coccolini F, Trevisan M, Montori G, et al. Mortality rate and antibiotic resistance in complicated diverticulitis: report of 272 consecutive patients worldwide: a prospective cohort study. Surg Infect (Larchmt). 2017;18(6):716–21.