Evaluation of anti-aging effects of swimming exercise on inflammatory parameters in D-galactose-treated Wistar albino male rats

Sriram B. S.; Ravichandra V.; Pooja K. M.; Jayanthi M. K.

doi:10.18203/2319-2003.ijbcp20262858

Authors

Sriram B. S. Department of Pharmacology, Sri Siddhartha Institute of Medical Sciences and Research Centre, SSAHE (Deemed to be University), T. Begur, Nelamangala Taluk, Bangalore Rural District, Karnataka, India https://orcid.org/0000-0003-1807-7690
Ravichandra V. Department of Pharmacology, K. S. Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India
Pooja K. M. Department of Pharmacology, Sri Siddhartha Institute of Medical Sciences and Research Centre, SSAHE (Deemed to be University), T. Begur, Nelamangala Taluk, Bangalore Rural District, Karnataka, India https://orcid.org/0009-0009-2320-5475
Jayanthi M. K. Department of Pharmacology, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20262858

Keywords:

Aging, C-reactive protein, D-galactose, Inflammation, Interleukin-6, Swimming exercise

Abstract

Background: The present study was undertaken to investigate the anti-ageing effect of swimming exercise on inflammatory parameters in D-galactose-induced Wistar albino male rats.

Methods: Wistar albino rats were divided into four groups, namely, normal control, D-galactose-treated group (positive control), normal control with swimming exercise, and D-galactose-treated rats with swimming exercise. The experiment was conducted for 42 days. D-galactose was administered as a compound to induce ageing-like changes, and swimming exercise was used as a non-pharmacological treatment. Plasma was separated from blood samples on the 43^rd day for estimation of inflammatory markers, interleukin-6 (IL-6) and c-reactive protein (CRP) taken from the tail vein.

Results: The plasma levels of IL-6 and CRP were significantly higher in the D-galactose-treated rats than in the normal control rats, suggesting an enhanced inflammatory response. The swimming exercise significantly reduced IL-6 and CRP levels in D-galactose-treated rats compared with the positive control group.

Conclusions: Swimming exercise was found to have a significant anti-inflammatory and anti-aging effect on Wistar albino male rats treated with D-galactose, as the plasma levels of IL-6 and CRP were reduced. Therefore, swimming exercise could be regarded as a useful non-pharmacological method to prevent inflammatory changes associated with aging.

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