Antihyperlipidemic potential of methanolic extract of whole plant Chlorophytum comosum (Thunb.) Jacques in poloxamer 407 induced hyperlipidemia in Wistar Albino rats
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20261966Keywords:
Hyperlipidaemia, Chlorophytum comosum (Thunb.) Jacques, Lipid profile, Poloxamer 407Abstract
Background: Hyperlipidaemia is a major risk factor for cardiovascular diseases, and natural remedies are being explored for safer therapeutic options. Chlorophytum comosum (Thunb.) Jacques has potential medicinal properties, but its antihyperlipidemic activity has not been thoroughly investigated. The objective was to evaluate the acute oral toxicity and antihyperlipidemic potential of the methanolic extract of Chlorophytum comosum (MECC) in Wistar Albino rats.
Methods: Acute oral toxicity was assessed following OECD 2001 guidelines at doses of 300 mg/kg and 2000 mg/kg. Hyperlipidaemia was induced using Poloxamer 407 (1 g/kg, i.p.). Animals were treated with MECC at low and high doses (200 and 400 mg/kg) for 21 days, while atorvastatin (10 mg/kg) was used as the standard. Body weight, lipid profile parameters (total cholesterol, triglycerides, LDL, VLDL, HDL), and liver histopathology were evaluated.
Results: MECC showed no mortality or significant adverse effects, indicating its safety. Treatment with MECC resulted in dose-dependent improvements in body weight and lipid profile parameters, comparable to those observed with atorvastatin. Histopathological analysis revealed that high-dose MECC maintained near-normal hepatic architecture, indicating hepatoprotective effects.
Conclusion: MECC is non-toxic and exhibits significant antihyperlipidemic activity, suggesting its potential as a therapeutic agent for managing hyperlipidaemia.
References
Lad SS, Kolhe SU. Evaluation of antihyperlipidemic potential of aqueous corm extract of Colocasia esculenta in experimental model of rats. Pharmacol Res Mod Chin Med. 2023;9:100307.
Balamurugan G, Shantha A. Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats. J Pharm Bioallied Sci. 2010;2(4):350-5.
Su L, Mittal R, Ramgobin D, Jain R, Jain R. Current Management Guidelines on Hyperlipidemia: The Silent Killer. J Lipid. 2021;2021:9883352.
Hill MF, Bordoni B. Hyperlipidemia. StatPearls. Treasure Island (FL): StatPearls Publishing. 2023.
Gosain S, Ircchiaya R, Sharma PC, Thareja S, Kalra A, Deep A, Bhardwaj TR. Hypolipidemic effect of ethanolic extract from the leaves of Hibiscus sabdariffa L. in hyperlipidemic rats. Acta Pol Pharm. 2010;67(2):179-84.
Mosa AU, Abd-Alkareem Z, Naser IH. Hyperlipidaemia: pathophysiology, causes, complications, and treatment. Biomed Pharmacol J. 2014;7(2).
Tripathi KD. Essentials of medical pharmacology. 8th ed. New Delhi: Jaypee Brothers medical Publishers. 2019.
Rawal P, Ramesh C, Sowmya BA, Lingam R. Determination of lipid lowering properties of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in Wistar rats. J Phytopharmacol. 2023;12(4):272-5.
Kavya P, Theijeswini RC, Gayathri M. Phytochemical analysis, identification of bioactive compounds using GC-MS, in vitro and in silico hypoglycemic potential, in vitro antioxidant potential, and in silico ADME analysis of Chlorophytum comosum root and leaf. Front Chem. 2024;12:1458505.
Rzhepakovsky IV, Areshidze DA, Avanesyan SS, Grimm WD, Filatova NV, Kalinin AV, et al. Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq. Molecules. 2022;27(3):762.
Shaikh J, Patil M. Qualitative tests for preliminary phytochemical screening: an overview. Int J Chem Stud. 2020;8(2):603-8.
Khadabadi SS, Deore SL, Baviskar BA. Experimental Phytopharmacognosy. A (1.1-1.6). Nirali Prakashan. 2019.
Khandelwal RK. Practical pharmacognosy. 2nd edition. Nirali Prakashan. 1995.
Organisation for Economic Co-operation and Development. OECD Guideline for testing of chemicals: Acute oral toxicity – Acute toxic class method (Test No. 423). Paris: OECD Publishing. 2001.
Ocheleka IM, Bawa I, Abutu AO. Phytochemical Analiysis and effect of methanolic root extract of Moringa oleifer on Haematological parameters and Body weight in poloxamer 407 Induce hyperlipidemic albino rats. Int J Modern Sci Technol. 2020; 5(7);172-181.
Reddy MM, Dhas Devavaram J, Dhas J, Adeghate E, Starling Emerald B. Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats. Pharm Biol. 2015;53(8):1133-40.
Downloads
Published
How to Cite
Issue
Section
