Euphorbia prostrata extract-based combination therapy in diabetic wound healing: clinical outcomes from a case report

Abstract

Chronic wounds in patients with diabetes mellitus remain a major clinical challenge due to impaired microcirculation, persistent inflammation and delayed collagen remodeling, often resulting in prolonged morbidity and consideration of surgical intervention. We report the successful conservative management of a chronic non-healing leg wound in a 55-year-old woman with poorly controlled type 2 diabetes mellitus who presented with a painful wound of more than two months’ duration, unresponsive to routine surgical outpatient department (OPD) dressings and initially advised for skin grafting. The patient was treated with a combination of EP extract therapy Sitcom cream dressing twice daily 3 months and Sitcom Forte tablet 1 BD x1 month and OD x 2 months alongside with antidiabetic medication. Early wound healing and clinical response was noted within 7-10 days, including pain reduction and improved granulation tissue quality. Progressive wound size reduction from peripheral wound towards centre, epithelialization and ultimately complete wound closure with minimal scarring were achieved by end of three months, importantly by sparing wound skin grafting and no local or systemic adverse effects reported. This case suggests that Euphorbia prostrata–topical and oral combination was having significant wound healing potential in diabetic patients, possibly related to its anti-inflammatory, antioxidant, venotonic and hemostatic properties. Larger controlled studies are warranted to confirm efficacy and define its role within comprehensive diabetic wound care.