To evaluate the creatinine clearance and compare nephrotoxic potential of amikacin and gentamicin, in post-operative patients with normal baseline renal function
Keywords:Amikacin, Gentamicin, Nephrotoxicity, Creatinine
Background: The majority of infections on any surgical ward are usually due to one or more of the gram-negative bacilli. Among the different groups of antimicrobials that have been used to treat these infections, Aminoglycoside antibiotics such as Amikacin and Gentamicin are the most commonly used.
Methods: The study is 1 year, non-interventional, prospective study of patients administered either Amikacin or Gentamicin following surgery carried out in surgery ward in co-ordination with department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre Moradabad.
Results: The mean difference in final and initial serum creatinine values were observed to be 0.32 and 0.52 with a standard deviation of 0.228 and 0.387 in AM and GM group respectively. This difference was statistically significant with p value of 0.007. The mean difference in final and initial creatinine clearance values were observed to be 18.82 and 24.76 with a standard deviation of 10.14 and 11.93 in AM and GM group respectively. This difference was also statistically significant with p-value of 0.013. Nephrotoxicity occurred in 9 out of 50 patients (18%) in AM group out of which 12% were male and 6% were female whereas in case of GM group nephrotoxicity occurred in 16 out of 50 patients (32%) in which 26% were male and 6% were female.
Conclusions: From this study we can conclude that Gentamicin is more nephrotoxic and causes greater fall in creatinine clearance although the dose of Gentamicin administered is much lower compared to Amikacin.
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