Published: 2017-01-05

Fluconazole induced multifocal bullous eruptions: a case report

Subhankar Choudhury, Bhulan Prasad Loc, Rati Ranjan Debbarma, Arijit Das


The term bullous drug eruption refers to adverse drug reactions that result in fluid filled blisters. Blistering can be due to various medications. A 22 year old primigravida developed bullous lesions on upper limbs, lower legs and face after taking six doses of lumether forte (artemether 80 mg + lumefantrine 480 mg themis medicare ltd) and difenac plus (diclofenac 50 mg + paracetamol 500 mg intermed), and single dose of flucan (fluconazole 150 mg Bombay tablet Mfg co) and mebex (mebendazole 100 mg Cipla Limited). She had a previous history of localized bullous eruption 2 years back after taking a single dose of forcan (fluconazole 150 mg Cipla Limited) for vaginal candidiasis. There are reported cases of bullous eruptions due to diclofenac, mebendazole and paracetamol. However in our case past history of localized bullous eruptions after taking fluconazole, made it superior to other offenders to be suspected as the “probable” culprit. Naranjo causality score was (…+5…).


Fluconazole, Bullous eruption, Candidiasis, Naranjo causality score

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