A rare case of imatinib mesylate induced acute kidney injury

Authors

  • Ratna Agrawal Department of Pharmacology, V. S. S. Medical College, Burla, Sambalpur, Odisha, India
  • Kaustav Saha Department of Pharmacology, V. S. S. Medical College, Burla, Sambalpur, Odisha, India
  • Sabita Mohapatra Department of Pharmacology, V. S. S. Medical College, Burla, Sambalpur, Odisha, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162491

Keywords:

Chronic myeloid leukemia, Imatinib, Renal failure, Creatinine

Abstract

Imatinib is a revolutionary targeted molecule strikingly successful in chronic phase of chronic myeloid leukemia and higher doses are beneficial in the accelerated phase of the disease. It’s known adverse effects include abdominal pain, vomiting, fluid retention, periorbital edema, pleural effusion, myalgia, liver damage and congestive heart failure. Renal damage due to this drug has not been well reported. In this case, the patient developed acute kidney injury as evidenced by raised creatinine level after two months of administration of imatinib mesylate. At 4th visit, the levels of urea and creatinine were significantly above the upper normal limit. The patient was kept under supervision of his renal status and at the starting of 5th visit decision was made to change the drug from imatinib to nilotinib. Currently the patient is tolerating nilotinib well. Causality assessment using WHO scale revealed imatinib to have possibly caused this rare adverse reaction.

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References

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Published

2017-01-05

How to Cite

Agrawal, R., Saha, K., & Mohapatra, S. (2017). A rare case of imatinib mesylate induced acute kidney injury. International Journal of Basic & Clinical Pharmacology, 5(4), 1678–1680. https://doi.org/10.18203/2319-2003.ijbcp20162491

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Section

Case Reports