Analysis of antidiabetic drug utilization patterns in type 2 diabetes patients: a perspective on real-time prescribing practices

Bashir Surajo; Ziyaurrahman Khan; M. Shadab; Naureen Khan; Mudassir Sada; Mohammad Ahmad; M. Sohel Akhter; Ayasa Parveen

doi:10.18203/2319-2003.ijbcp20243033

Authors

Bashir Surajo Department of Pharmacy Practice, Integral University, Lucknow, Uttar Pradesh, India https://orcid.org/0009-0000-1742-4502
Ziyaurrahman Khan Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India https://orcid.org/0009-0001-1108-2131
M. Shadab Department of Pharmacy Practice, Integral University, Lucknow, Uttar Pradesh, India https://orcid.org/0009-0005-1155-5305
Naureen Khan Department of Pharmacy Practice, Integral University, Lucknow, Uttar Pradesh, India https://orcid.org/0009-0002-9211-1703
Mudassir Sada Department of Pharmacy Practice, Integral University, Lucknow, Uttar Pradesh, India https://orcid.org/0009-0002-2537-8424
Mohammad Ahmad Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
M. Sohel Akhter Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
Ayasa Parveen Department of General Medicine, Integral Institute of medical science and research Hospital, Uttar Pradesh, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20243033

Keywords:

Type-2 diabetes, Drug Utilization, Prescribing practice, Antidiabetic drugs, Prescription pattern

Abstract

Background: Type 2 diabetes is a most common health problem associated with significant morbidity and mortality worldwide, evaluation of drug utilization pattern is very crucial and significant in order to promote the rational use of drugs in treatment of diabetes, and offer insights in to the actual patterns of drug use. The objective is to evaluate drug utilization pattern of antidiabetic drugs among type 2 diabetic patients at Integral Institute of Medical Science & Research.

Methods: This is a prospective observational study involving 100 subjects conducted for a period of 6 months after approval by Institutional Ethics Committee (IEC) of Integral University at IIMS and R Hospital. Informed consent was obtained from all the participants. Data gathered was examined using descriptive statistics and compared to the standard guidelines. Drug utilization pattern was studied and evaluated to analyse the pattern of drug therapy among type 2 diabetics.

Results: Antidiabetic drugs were given 198 times among the 100 participants, averaging 2 antidiabetic drugs per prescription, Insulin therapy (58.58%) and Metformin (20.20%) were the most prescribed medications, combination therapy was common, with 66% of patients particularly with Glimepiride (DPP4 Inhibitor) at 10.61%. Most prescriptions were given by generic name (55%) and 90% of the drugs prescribed were from the WHO essential medicines. Most patients were aged 51-60 years, with a nearly equal gender distribution.

Conclusion: The study highlights the prescribing patterns and characteristic use of antidiabetic medications. These findings provide valuable insights into the current prescribing practices in type-2 DM treatment and can contribute to optimizing treatment strategies for better patient outcomes.

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References

World Health Organization. Introduction to drug utilization research. 2003. Available at: https://www.who.int/publications/i/item/8280820396. Accessed on 15th May 2023.

Sada M, Khan S, Khan MU, Khan MM, Kumar P, Ahamad U. Drug utilization and prescribing pattern in the treatment of urolithiasis: a perspective on World Health Organization recommendations. International J Bas Clin Pharmacol. 2024;13(3):371.

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Prac. 2022;183:109119.

Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgra Med J. 2016;92(1084):63-9.

Zhou T, Xu X, Du M, Zhao T, Wang J. A preclinical overview of metformin for the treatment of type 2 diabetes. Biomed Pharmaco. 2018;106:1227-35.

Barnett A. DPP‐4 inhibitors and their potential role in the management of type 2 diabetes. International journal of clinical practice. 2006;60(11):1454-70.

Vallon V, Thomson SC. Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia. 2017;60(2):215-25.

Tefera BB, Getachew M, Kebede B. Evaluation of drug prescription pattern using World Health Organization prescribing indicators in public health facilities found in Ethiopia: systematic reviews and meta-analysis. Journal of pharmaceutical policy and practice. 2021;14:1-10.

Ministry of health and family welfare, government of India. national list of essential medicines (NLEM). 2023. Available at: https://main.mohfw. Accessed on 15th May 2023

WHO model list of essential medicines-23rd list. 2023. Available at: https://www.who.int/publication. Accessed on 29th July 2022.

Kanaya AM, Grady D, Barrett-Connor E. Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis. Arch Inter Med. 2002;162(15):1737-45.

Wallia A, Molitch ME. Insulin therapy for type 2 diabetes mellitus. JAMA. 2014;311(22):2315-25.

Tanwar S, Acharya A, Hasan N. Assessment of drug utilization pattern of antidiabetic drugs in type-2 diabetes outpatient of a tertiary care teaching hospital western Rajasthan. Inter J Basic Clin Pharmacol. 2021;10(4):368-73.

Acharya, Leelavathi D. "Study of drug related problems in type ii diabetes mellitus patients with comorbidities in a tertiary care hospital -a retrospective study". Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations. 2020. Available at: https://impressions.manipal.edu.

Tomlinson B, Patil NG, Fok M, Chan P, Lam CW. The role of sulfonylureas in the treatment of type 2 diabetes. Expert Opinion on Pharmacotherapy. 2022;23(3):387-403.

Cheng D, Fei Y, Liu Y, Li J, Chen Y, Wang X, et al. Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis. PLoS One. 2014;9(10):111543.

Brunetti L, Kalabalik J. Management of type-2 diabetes mellitus in adults: focus on individualizing non-insulin therapies. Pharmacy and therapeutics. 2012;37(12):687.

Biswas NR, Biswas RS, Pal PS, Jain SK, Malhotra SP, Gupta AS, et al. Patterns of prescriptions and drug use in two tertiary hospitals in Delhi. Ind J Physio Pharmacol. 2000;44(1):109-12.

Elseviers M, Wettermark B, Almarsdóttir AB, Andersen M, Benko R, Bennie M, et al. Drug utilization research: methods and applications. 2016;97:81-91.