A comparative study of hypolipidemic effect of atorvastatin and Coriandrum sativum in triton-induced hyperlipidemic albino rat model

Pooja M.; Puneeth A.

doi:10.18203/2319-2003.ijbcp20243029

Authors

Pooja M. Department of Pharmacology, Father Muller Medical College, Mangaluru, Karnataka, India
Puneeth A. Department of Biochemistry, Father Muller Medical College, Mangaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20243029

Keywords:

Atorvastatin, Coriander sativum, Hyperlipidemia, Triton

Abstract

Background: Hyperlipidemia is the main factor responsible for coronary artery disease. Atorvastatin commonly used, as a competitive inhibitor of HMG-Co-A reductase, is known to reduce LDL and triglyceride levels and increase HDL levels. Coriandrum sativum (Coriander) belongs to the Apiaceae family and has hypolipidemic, antidiabetic, and antioxidant properties. Triton WR1339 has been used by several studies to induce hypercholesterolemia in animals which acts on both the synthesis and excretory phase. This study aimed to compare the hypolipidemic effect of Coriandrum sativum and atorvastatin in triton-induced hyperlipidemic rats.

Methods: Following approval from the Institutional Animal Ethics committee, 36 Wistar albino rats were divided into 6 groups of 6 animals each. Triton 200mg IP was administered to all the groups except Group 1 (control). Groups 3 and 4 received Coriander extract 300mg/kg and Atorvastatin 80mg/kg orally with Triton. Groups 5 and 6 received Coriander extract and Atorvastatin respectively 22 hours later. Lipid profile was estimated 24 hours before, 24 and 48 hours after administering Triton.

Results: In the synthesis phase, there is a statistically significant increase in the lipid levels in Groups 2, 5, and 6 compared to Groups 3 and, 4 indicating hypolipidemic effects of both Coriander extract and Atorvastatin. In the excretory phase, all groups have shown a decrease in lipid levels but a decrease in total cholesterol level in Group 5 compared to Group 3 was significant.

Conclusions: Atorvastatin and Coriander extract both affect the lipid levels in the synthesis and excretory phase. Even though coriander cannot replace atorvastatin in the management of hyperlipidemia, it can be used as an adjuvant to atorvastatin to reduce the cost effects and adverse reactions caused by allopathic medicines.

Metrics

Metrics Loading ...

References

Bharadwaj S, Bhattacharjee J, Bhatnagar M, Tyagi S. Atherogenic Index of Plasma, Castelli risk Index and Atherogenic coefficient- new parameters in assessing cardiovascular risk. Int J Pharm Biolog Sci. 2013;3(3):359-64.

Pandit R, Khatri I, Sawarkar S. Spices and condiments: safer option for treatment of hyperlipidemia. Ind J Pharm Biolog Res. 2015;3(3):24.

Munshi RP, Joshi SG, Rane BN. Development of an experimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart disease. Ind J Pharmacol. 2014;46(3):270-6.

Baron R. Current Medical Diagnosis and Treatment. McGraw-Hill; 2015.

Shetty JK, Jeppu AK, Bhagavath P, Shilpa SK, Rashmi M, Kamath V, et al. Lipid profile and Atherogenic index of plasma (AIP) in diabetic non smokers and smokers in coastal Karnataka. Int J AJ Instit Medi Sci. 2012;1(2):93-7.

Bersot TP. Drug Therapy for Hypercholesterolemia and Dyslipidemia. In: Brunton LL, Chabner BA, Knollman BC, Eds., Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. McGraw-Hill, New York; 2011:877-908.

Malloy M, Kane J. Basic and Clinical Pharmacology. 13th ed. McGraw-Hill; 2015.

Joshi S, Jain P. A review on Hypolipidemic and antioxidant potential of some medicinal plants. World J Pharm Pharmac Sci. 2014;3(11):357-380.

Dhanapakiyam P, Joseph J, Ramaswamy V, Moorthi M, Kumar S. The cholesterol lowering property of coriander seeds (Coriandrum sativum): Mechanism of action. J Environm Biol. 2008;29(1):53-6.

Rohilla A, Dagar N, Rohilla S, Dahiya A, Kushnoor A. Hyperlipidemia-a deadly pathological condition. Int J Curr Pharm Res. 2012;4(2):15-8.

Bhat S, Kaushal P, Kaur M, Sharma H. Coriander (Coriandrum sativum L.): Processing, nutritional and functional aspects S. Afr J Plant Sci. 2014;8(1):25-33.

Lal A, Kumar T, Murthy B, Pillai S. Hypolipidemic effect of Coriander sativum L in triton-induced hyperlipidemic rats. Ind J Experim Biol. 2004;42(9):909-12.

Bertges L, Mourão C, Souza J, Cardoso V. Hyperlipidemia induced by Triton WR1339 (Tyloxapol) in Wistar rats. Revista Brasileira de Ciências Médicas e da Saúde. 2011;1(1):32-34.

Pandit K, Karmarkar S, Bhagwat A.Evaluation of Antihyperlipidemic activity of Ficus hispida Linn Leaves in Triton WR-1339 (Tyloxapol) induced hyperlipidemia in mice. Int J Pharm Pharmac Sci. 2011;3(5):188-91.

Vogel HG, Vogel WH. Drug Discovery and Evaluation, Pharmacological assays. 2nd ed. Springer; 2002:1106-1107.

Kumar G, Srivastava A, Sharma SK, Gupta YK. The hypolipidemic activity of Ayurvedic medicine, Arogyavardhini vati in Triton WR-1339-induced hyperlipidemic rats: a comparison with fenofibrate. J Ayurv Integrat Medi. 2013;4(3):165.

Joshi SC, Sharma N, Sharma P. Antioxidant and lipid lowering effects of coriandrum sativum in cholesterol. Internat. J. Pharm. and Pharmac. Sci. 2012;4:4-7.

Anfenan MLK. Study the effect of consumption of coriander and vitamin B6 on rats suffering from hyperlipdemia. Wor Appl Sci J. 2014;30(11):1504-9.