Emerging trends in precision medicine and its impact in pharmacy practice

Abhishek S. Krishna; Harikrishnan V. Nair; Shaiju S. Dharan; Keerthi G. S. Nair

doi:10.18203/2319-2003.ijbcp20242441

Authors

Abhishek S. Krishna Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Trivandrum, Kerala, India
Harikrishnan V. Nair Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Trivandrum, Kerala, India
Shaiju S. Dharan Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Trivandrum, Kerala, India
Keerthi G. S. Nair Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Trivandrum, Kerala, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20242441

Keywords:

Biomarkers, Genetics, Precision medicine, Pharmacogenomics, Pharmacy practice, Targeted therapies

Abstract

Precision medicine is revolutionizing healthcare by tailoring treatments to an individual’s unique genetic makeup, life style, and environment. This abstract explores the latest trends in precision medicine and discusses how it impacts pharmacy practice, including the development of targeted therapies and the role of pharmacogenomics in optimizing drug selection and dosage. Exciting advancements in this field offer the potential for improved patient outcomes and more precise medication management.

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References

Naithani N, Sinha S, Misra P, Vasudevan B, Sahu R. Precision medicine: Concept and tools. Med J Armed Forces India. 2021;77(3):249-57.

Cecchin E, Stocco G. Pharmacogenomics and Personalized Medicine. Genes (Basel). 2020;11(6):679.

Sadee W, Wang D, Hartmann K, Toland AE. Pharmacogenomics: Driving Personalized Medicine. 2023;75(4):789-814.

Akhoon N. Precision medicine: A new paradigm in therapeutics. Int J Prev Med. 2021;12:4.

Stone A. Precision medicine: Health care tailored to you. The White House Blog. 2016;2:54.

Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793-5.

Delpierre C, Lefevre T. Precision and personalized medicine: What their current definition says and silences about the model of health they promote. Implication for the development of personalized health. Front Sociol. 2023;8:1112159.

Goetz LH, Schork NJ. Personalized medicine: motivation, challenges, and progress. Fertil Steril. 2018;109(6):952-63.

Aronson SJ, Rehm HL. Building the foundation for genomics in precision medicine. Nature. 2015;526(7573):336-42.

Freimuth RR, Formea CM, Hoffman JM, Matey E, Peterson JF, Boyce RD. Implementing Genomic Clinical Decision Support for Drug-Based Precision Medicine. CPT Pharmacometrics Syst Pharmacol. 2017;6(3):153-5.

Horton RH, Lucassen AM. Recent developments in genetic/genomic medicine. Clin Sci. 2019;133(5):697-708.

Johnson KB, Wei WQ, Weeraratne D, Frisse ME, Misulis K, Rhee K, et al. Precision medicine, AI, and the future of personalized health care. Clin Transl Sci. 2021;14(1):86-93.

Saeed RF, Awan UA, Saeed S, Mumtaz S, Akhtar N, Aslam S. Targeted Therapy and Personalized Medicine. Cancer Treat Res. 2023;185:177-205.

Linnea M Baudhuin, Leslie G Biesecker, Wylie Burke, Eric D Green, Robert C Green. Predictive and precision medicine with genomic data. Clinical Chemistry. 2020;66(1):33-41.

Kudzma EC, Carey ET. Pharmacogenomics: personalizing drug therapy. Am J Nurs. 2009;109(10):50-7.

Stratton TP, Olson AW. Personalizing personalized medicine: the confluence of pharmacogenomics, a person’s medication experience and ethics. Pharmacy (Basel). 2023;11:3.

Nogueiras-Alvarez R. Pharmacogenomics in clinical trials: an overview. Front Pharmacol. 2023; 14:1247088.

Service RF. Pharmacogenomics. Going from genome to pill. Science. 2005;308(5730):1858-60.

Rodriguez-Vicente AE, Lumbreras E, Hernandez JM, Martin M, Calles A, Otin CL, et al. Pharmacogenetics and pharmacogenomics as tools in cancer therapy. Drug Metab Pers Ther. 2016;31(1):25-34.

Ingelman SM, Nebert DW. Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling. Hum Genomics. 2023;105:17.

Hiratsuka M, Sasaki T, Mizugaki M. Genetic testing for pharmacogenetics and its clinical application in drug therapy. Clin Chim Acta. 2006;363(1-2):177-86.

Roberts B, Cooper Z, Lu S, Stanley S, Majda BT, Collins KRL, et al. Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review. Front Pharmacol. 2023;14:1267294.

Slikker W J. Biomarkers and their impact on precision medicine. Exp Biol Med. 2018;243(3):211-2.

Gyawali B. Point: the imprecise pursuit of precision medicine: are biomarkers to blame? J Natl Compr Canc Netw 2017;15:859-62.

Bakker E, Starokozhko V, Kraaijvanger JWM, Heerspink HJL, Mol PGM. Precision medicine in regulatory decision making: Biomarkers used for patient selection in European Public Assessment Reports from 2018 to 2020. Clin Transl Sci. 2023;16: 2394-412.

Dregely I, Prezzi D, Kelly-Morland C, Roccia E, Neji R, Goh V. Imaging biomarkers in oncology: Basics and application to MRI. J Magn Reson Imaging. 2018;48(1):13-26.

Schweitzer M. Biomarkers, bioindicators, molecular imaging, functional imaging, precision medicine, and the search for intelligent life in the universe. J Magn Reson Imaging. 2016;44(1):11.

Giansanti D. Precision medicine 2.0: How digital health and ai are changing the game. J Pers Med. 2023;13(7):1057.

Ginsburg G S, Phillips K A. Precision Medicine: From Science to Value. Health Aff. 2018;37:694-701.

Fernandez-Luque L, Al Herbish A, AI Shammari R, Argente J, Bin-Abbas B, Deeb A, et al. Digital health for supporting precision medicine in pediatric endocrine disorders: opportunities for improved patient care. Front Pediatr. 2021;9:715705.

Johnson KB, Wei WQ, Weeraratne D, Frisse ME, Misulis K, Rhee K, et al. Precision medicine, ai, and the future of personalized health care. Clin Transl Sci. 2021;14(1):86-93.

Wang F, Preininger A. AI in Health: State of the art, challenges, and future directions. Year Med Inform. 2019;28(1):16-26.

Topol EJ. High performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56.

Korngiebel DM, Thummel KE, Burke W. Implementing Precision Medicine: The Ethical Challenges. Trends Pharmacol Sci. 2017;38(1):8-14.

Erdmann A, Rehmann-Sutter C, Bozzaro C. Patients’ and professionals’ views related to ethical issues in precision medicine: a mixed research synthesis. BMC. Med Ethics. 2021;22(1):116.

Evans WE. Pharmacogenomics: marshalling the human genome to individualize drug therapy. GUT. 2003;52:10-8.

Ashley EA. The precision medicine initiative: a new national effort. JAMA. 2015;313:2119-20.

Olson S, Beachy SH, Giammaria CF, Berger AC. Integrating large-scale genomic information into clinical practice. The National Academies Press; Washington, DC, USA. 2012. Available at: www.ncbi.nlm.nih.gov/books.

Joaeo VC. Ethical and legal challenges of personalized medicine: Paradigmatic examples of research, prevention, diagnosis, and treatment. Revista Portuguesa de SaA de Pablic. 2014;32(2):164-80.

Eric T. Why does the shift from personalized medicine to precision health and wellness genomics matter? Am J of Ethics. 2018;20(9):881-90.

Carter BL. Evolution of clinical pharmacy in the USA and future directions for patient care. Drugs aging. 2016;33(3):169-77.

Papadopoulou P, Lytras M. Advancing precision medicine in medical education: Integrated, precise, and data-driven smart solutions. Appl Res. 2023;2:202200131.

Singh AK, Malviya R, Verma S. Personalized Medicine: Advanced Treatment Strategies to Revolutionize healthcare. Curr Drug Res Rev. 2023;15(2):101-4.

Kennedy MJ. Personalized medicines-are pharmacists ready for the challenge? Integrated Pharmacy Research and Practice. 2018;7:113-23.

Kennedy MJ, Phan H, Benavides S, Potts A, Sorensen S. The role of the pediatric pharmacist in personalized medicine and clinical pharmacogenomics for children: Pediatric pharmacogenomics working group. J Pediatr Pharmacol Ther. 2011;16(2):118-22.

Naithani N, Atal AT, Tilak TVSVGK, Vasudevan B, Misra P, Sinha S. Precision medicine: Uses and challenges. Med J Armed Forces India. 2021;77(3):258-65.

Love-koh J, Peel A, Rejon-Parrilla JC, Ennis K, Lovett R, Manca A, et al. The future of precision medicine: potential impacts for health technology assessment. Pharmacoeconomics. 2018;36(12):1439-51.

Ory MG, Adepoju OE, Ramos KS, Silva PS, Vollmer DD. Health equity innovation in precision medicine: current challenges and future directions. Front Public Health. 2023;11:1119736.

Callier SL. The use of racial categories in precision medicine research. Ethn Dis. 2019:651-8.

Badhe Pravin. Personalized medicine: the future of modern medicine. Authorea. 2021:1-9.

Mathur S, Sutton J. Personalized medicine could transform healthcare. Biomed Rep. 2017;7(1):3-5.

Amelio I, Bertolo R, Bove P. Liquid biopsies and cancer omics. Cell Death Discover. 2020;6(1):1-8.

Wilson JF, Weale ME, Smith AC, Gratrix F, Fletcher B, Thomas MG. Population genetic structure of variable drug response. Nat Genet. 2001;29:265-9.

Liu X, Luo X, Jiang C, Zhao H. Difficulties, and challenges in the development of precision medicine. Clin Genet. 2019;95(5):569-74.

Mc Gonigle V. The collective nature of personalized medicine. Genet Res. 2016;98:3.

Duffy DJ. Problems, challenges and promises: perspectives on precision medicine. Brief Bioinform. 2016;17(3):494-504.

Hood L, Friend SH. Predictive, personalized, preventive, participatory cancer medicine. Nat Rev Clin Oncol. 2011;8:184-7.

Xue Y, Lameijer EW, Ye K, Zhang K, Chang S. Precision medicine: What challenges are we facing? Genomics Proteomics Bioinformatics. 2016;14(5):253-61.

Beckmann JS, Lew D. Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities. Genome Med. 2016;8(1):134.