Evaluation of anti-epileptic properties of Evolvulus alsinoides by pentylenetetrazole-induced mouse model

P. S. Venkatesan; M. Eswarya; M. Madhavaselvi

doi:10.18203/2319-2003.ijbcp20242427

Authors

P. S. Venkatesan Mass Biotech Private Limited, Padi, Chennai, Tamil Nadu, India
M. Eswarya Mass Biotech Private Limited, Padi, Chennai, Tamil Nadu, India
M. Madhavaselvi Mass Biotech Private Limited, Padi, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20242427

Keywords:

Evlolvulus alsinoides, PTZ, Diazepam, Epilepsy, Morning glory, Mouse model

Abstract

Background: A common neurological condition that affects people of all ages, epilepsy is defined by recurring seizures that have serious negative effects on the nervous system, cognition, psychology, and social interactions. Anti-epileptic drug (AED) side effects continue to be a significant concern despite advances in pharmacotherapy, as they can lower quality of life and adherence. Herbal medicines are becoming more and more popular as complementary and alternative therapies as a result.

Methods: Using a mouse seizure model caused by PTZ (Pentylenetetrazole), this study examines the anticonvulsant efficacy of a traditional medicinal plant called Evolvulus alsinoides, often known as dwarf slender morning glory. The herb was mixed with 1.5% CMC and given to mice with various dosage levels.

Results: The effects of various doses of morning glory extract (50 mg/kg to 400 mg/kg body weight) on latency period and seizure duration were compared to those of a control group and a diazepam-treated group. In latency period, 300 mg/kg. b. wt group showed a long latency period of 222.5±47.68 (p<0.05) when comparing to other groups. Morning glory of dose 400 mg/kg b. wt eliminated tonic-clonic seizures in all animals (p<0.001).

Conclusions: These findings suggest that Evolvulus alsinoides has anti-epileptic properties in PTZ-induced mice model.

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