A review on cardiovascular risk in rheumatoid arthritis

Authors

  • Ramya Balaprabha G. Department of Pharm D., CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India
  • Sri Vaishnavi P. Department of Pharm D., CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India
  • Harika Guptha M. Department of Pharm D., CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India
  • Krishna Sree N. Department of Pharm D., CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India
  • Rama Rao T. Department of Pharmacy, CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20241007

Keywords:

Cardiovascular risk factors, RA, CVD, Anti-rheumatic medications, Cardiac risk management, Inflammatory mediators

Abstract

A systemic inflammatory disease known as rheumatoid arthritis (RA) is distinguished by excessive cardiovascular disease (CVD) morbidity and death. Traditional CV risk factors may partially contribute to CV disease in RA. Shared inflammatory mediators, post-translational modifications of peptides/proteins and subsequent immune responses, changes in the composition and function of lipoproteins, increased oxidative stress, and endothelial dysfunction are some of the mechanisms that link RA and CVD. The detailed pathogenetic pathway by which this association between RA and CVD might be explained is still not entirely known. It is crucial for controlling cardiovascular risk in people with RA. Optimizing care of traditional risk factors in addition to those inherent to RA is necessary to lessen the burden caused by CVD. The potential effect of planned Cardiac risk management in these individuals is highlighted by findings for under diagnosis and inadequate treatment of conventional CVD risk factors in RA. Present cardiovascular standards suggest RA patients to be examined for and treated for CVD risk factors without appropriate treatment goals. Utilizing potent anti-rheumatic medications that can reduce disease activity and treating the conventional CV risk factors should both be part of the therapy of CV risk in RA. There is currently insufficient scientific data to develop therapy targets for RA-related CVD risk factors. Thus, more study is required on the traditional CVD risk factor screening and management in RA patients.

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Published

2024-04-25

How to Cite

G., R. B., P., S. V., M., H. G., Sree N., K., & Rao T., R. (2024). A review on cardiovascular risk in rheumatoid arthritis. International Journal of Basic & Clinical Pharmacology, 13(3), 425–432. https://doi.org/10.18203/2319-2003.ijbcp20241007

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Review Articles