Clozapine induced pneumonitis: a case report
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20240997Keywords:
Antipsychotics, Agranulocytosis, Drug induced interstitial lung diseases, Resistant-schizophreniaAbstract
Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. Clozapine acts by blocking serotonin receptors in the brain, thereby reducing the symptoms of schizophrenia. Clozapine is usually restricted to the treatment of resistant cases of schizophrenia. Clozapine induced pneumonitis is a very rare adverse reaction and, one such incident in a 16-year-old Indian boy is intricated in this case report.
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References
Skeoch S, Weatherley N, Swift AJ, Oldroyd A, Johns C, Hayton C, et al. Drug-Induced Interstitial Lung Disease: A Systematic Review. J Clin Med. 2018;7(10):356.
Wahlbeck K, Cheine M, Essali A, Adams C. Evidence of Clozapine’s Effectiveness in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Trials. Am J Psychiatry. 1999;156(7):990-9.
Meyer JM. Chapter 16: Pharmacotherapy of psychosis and mania in Goodman and Gilman’s The pharmacological basis of therapeutics. McGraw Hill. 2011;442.
Aldridge G, Collins C, Croucher M. Clozapine-induced pneumonitis. Aust N Z J Psychiatry. 2013;47(12):1215-6.
Lewis A, Gibbs A, Hope-Gill B. Probable occupational pneumonitis caused by inhalation of crushed clozapine. Occup Med. 2012;62(5):385-7.
Torrico T, Crandall RO, Meza C, Abdijadid S. Clozapine-Induced Pneumonitis: A Case Report. Front Psychiatry. 2020;11:572102.
Bugge E, Nissen T, Wynn R. Probable clozapine-induced parenchymal lung disease and perimyocarditis: a case report. BMC Psychiatry. 2016;16:438.
Schoretsanitis G, Can-Jun R, Christopher R, Hélène V, De Las Cuevas C, Edoardo S et al. An update on the complex relationship between clozapine and pneumonia. Expert Rev Clin Pharmacol. 2021;14(2):145-9.