Clozapine induced pneumonitis: a case report

Authors

  • Sandeep M. Sasi Department of Pharmacology, CSM-Government Medical College, Satara, Maharashtra, India
  • Piyush Nama Government Medical College, Nagpur, Maharashtra, India
  • Smita Sontakke Department of Pharmacology, Government Medical College, Yawatmal, Maharashtra, India
  • Sanjivani Pande Department of Psychiatry, Government Medical College, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20240997

Keywords:

Antipsychotics, Agranulocytosis, Drug induced interstitial lung diseases, Resistant-schizophrenia

Abstract

Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. Clozapine acts by blocking serotonin receptors in the brain, thereby reducing the symptoms of schizophrenia. Clozapine is usually restricted to the treatment of resistant cases of schizophrenia. Clozapine induced pneumonitis is a very rare adverse reaction and, one such incident in a 16-year-old Indian boy is intricated in this case report.

References

Skeoch S, Weatherley N, Swift AJ, Oldroyd A, Johns C, Hayton C, et al. Drug-Induced Interstitial Lung Disease: A Systematic Review. J Clin Med. 2018;7(10):356.

Wahlbeck K, Cheine M, Essali A, Adams C. Evidence of Clozapine’s Effectiveness in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Trials. Am J Psychiatry. 1999;156(7):990-9.

Meyer JM. Chapter 16: Pharmacotherapy of psychosis and mania in Goodman and Gilman’s The pharmacological basis of therapeutics. McGraw Hill. 2011;442.

Aldridge G, Collins C, Croucher M. Clozapine-induced pneumonitis. Aust N Z J Psychiatry. 2013;47(12):1215-6.

Lewis A, Gibbs A, Hope-Gill B. Probable occupational pneumonitis caused by inhalation of crushed clozapine. Occup Med. 2012;62(5):385-7.

Torrico T, Crandall RO, Meza C, Abdijadid S. Clozapine-Induced Pneumonitis: A Case Report. Front Psychiatry. 2020;11:572102.

Bugge E, Nissen T, Wynn R. Probable clozapine-induced parenchymal lung disease and perimyocarditis: a case report. BMC Psychiatry. 2016;16:438.

Schoretsanitis G, Can-Jun R, Christopher R, Hélène V, De Las Cuevas C, Edoardo S et al. An update on the complex relationship between clozapine and pneumonia. Expert Rev Clin Pharmacol. 2021;14(2):145-9.

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Published

2024-04-25

How to Cite

Sasi, S. M., Nama, P., Sontakke, S., & Pande, S. (2024). Clozapine induced pneumonitis: a case report. International Journal of Basic & Clinical Pharmacology, 13(3), 386–388. https://doi.org/10.18203/2319-2003.ijbcp20240997

Issue

Section

Case Reports