Study of utilization of antimicrobial drugs and its resistance pattern in patients with septicemia at a tertiary care hospital

Apurva Anil Rayewar; Sandhya Shivajirao Hambarde; Rasika Purushottam Wanjari; Akshay Vishwasrao Bodke; Momin M. Abdul Mujeeb

doi:10.18203/2319-2003.ijbcp20240384

Authors

Apurva Anil Rayewar Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India
Sandhya Shivajirao Hambarde Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India
Rasika Purushottam Wanjari Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India
Akshay Vishwasrao Bodke Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India
Momin M. Abdul Mujeeb Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20240384

Keywords:

Antimicrobial drug resistance, Intensive care unit, Pseudomonas

Abstract

Background: Many types of bacteria can produce septicemia. The most common infections that lead to septicemia are urinary tract infections, pneumonia, nephritis and abdominal infections.

Methods: The study aims to assess the pattern of antimicrobial drugs used in septicemia and to assess the etiological organisms and their drug sensitivity and resistance pattern. Study participants admitted to tertiary health care centre and who are having septicemia were included in this prospective observational study. Blood culture, bronchial secretions were subjected to microbiological analysis. The etiological organisms, their drug sensitivity and resistance pattern and the outcome of drug therapy were recorded. The clinical course of the study participants was monitored till cure either the resolution of pneumonia. Qualitative data were analyzed using the chi-square test or Fischer's exact test and quantitative data using the independent t test.

Results: Mean duration of hospital stay in all patients 13.22±0.45 days and in resistance cases it was found 19.22±0.45 days. Mean duration of ICU stay in all patients was 4.34±0.45 days and in resistant cases mean duration of ICU stay was 8.18±0.45 days. Clinical outcome in overall admitted patients recovered was 97 patients (80.83%) death was 16 patients (13.33%). Clinical outcome in resistant patients recovered 16 patients (13.33%) and death 26 patients (21.66%).

Conclusions: The organisms had a varied sensitivity and resistance pattern. The clinical outcome was multifactorial.

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