Drug utilization study of anti-diabetic drugs in patients attending medicine outpatient department at a tertiary care hospital in Western Maharashtra
Keywords:T2DM, Biguanides, Sulfonylurea
Background: Studies on antidiabetic drug utilization are important for the optimization of drug therapy and rational prescription of drugs. The aim of the present study was to understand the trends in prescription pattern of oral anti-diabetic drugs among type 2 diabetes mellitus (T2DM) patients attending medicine outpatient department of tertiary care hospital of Western Maharashtra.
Methods: A prospective observational study was conducted at Medicine OPD of Government Medical College and Hospital, Miraj. All adult patients (≥18 years) diagnosed with T2DM and willing to give informed consent to participate in the study, were enrolled. The study was approved by Institutional Ethics Committee. The data was computed using MS excel and results were expressed as counts and percentages.
Results: Out of 72 T2DM patients enrolled, male population (58.33%) had higher prevalence than females (41.67%). Biguanides (63.16%) were the most commonly prescribed class of oral antidiabetic drugs followed by sulfonylureas (35.09%). Metformin (63.16%) was the most commonly prescribed oral antidiabetic drug followed by glimepiride (30.70%). Combination of oral antidiabetic drugs (OADs) were prescribed in 52.78% and 47.22% patients were prescribed single drug. ‘Metformin and glimepiride’ was the most commonly prescribed combination.
Conclusions: In a chronic disease like diabetes mellitus, constant follow up for successful management is a must. It also demands active participation by the patients. Continuing education for the clinicians to keep themselves abreast of the latest development will also contribute in the effective management of diabetes mellitus and rational prescription of antidiabetic drugs.
Rani J, Reddy S. Prescribing pattern of antidiabetic drugs in urban population of Hyderabad. Natl J Physiol Pharm Pharmacol. 2015;5:5-9.
Haghighatpanah M, Thunga G, Jha A, Mallayasamy S. Study on prescribing pattern of anti-diabetic drugs among type 2 diabetes Patients with complication in south indian teaching hospital. Asian J Pharm Clin Res 2016;9: 194-7.
Vengurlekar S, Shukla P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in indore city hospital. Indian J Pharm Sci. 2008;70(5):637-40.
Akila L, Sandozi T, Geetha Devi AK, Kumar JS, Balasubramanian A, Jamuna Rani R. Drug utilization study of oral anti-diabetic drugs at a tertiary care (SRM Medical College) hospital in Chennai. Int J Med Res. 2011;1:177-82.
Piette JD, Heisler M, Wagner TH. Problems paying out-of-pocket medication costs among older adults with diabetes. Diabetes Care. 2004;27(2):384-91.
Delamater AM. Improving patient adherence. Clin Diabetes 2006;24(2):71-7.
Tognoni G, Liberati A, Pellò L, Sasanelli F, Spagnoli A. Drug utilization studies and epidemiology. Rev Epidemiol Sante Publique. 1983;31(1):59-71.
Upadhyay DK, Palaian S, Ravishankar P, Mishra P, Sah AK. Study on the prescribing pattern in diabetic outpatients in a tertiary care teaching hospital in Nepal. JCDR. 2007;3:248-55.
Abdi SA, Churi S, Kumar YS. Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital. Indian J Pharmacol. 2012;44(2):210-4.
Ramesh R, Kumar SV, Gopinath S, Gavaskar B, Gandhiji G. Diabetic knowledge of rural community and drug utilization pattern in a tertiary care hospital. Int J Pharm Life Sci 2011;2(1):531-5.
Sivasankari V, Manivannan E, Priyadarsini SP. Drug utilization pattern of antidiabetic drugs in a rural area of Tamil Nadu, South India - A prospective, observational study. Int J Pharm Biol Sci. 2013;4(1):514-9.
Abbasi MY, Ali MA, Alshammari M. A prospective study on prescribing patterns of antidiabetic drugs. WJPPS. 2014;3:45-57.
Venkateswaramurthy N, Shajeem S, Sambathkumar R. Prescribing pattern of antidiabetic drugs in type-2 diabetic patients. Int J Pharm Sci Res. 2016;7:4550-55.
Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharm Ther. 2010;35(3):267-77.