DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20162467

Effect of co-administration of voglibose and vildagliptin on diabetic albino rats

Umashanker PD Keshri, Mukesh Kumar, Bhulan PD Loc, Manju Gari, Janardan Sharma, Rajiv Kumar

Abstract


Background: The progressive nature of type 2 diabetes usually requires a combination of two or more oral agents in long term. Studies have been done to support its relevance. This study was made to observe the possible additive or supra-additive effect of the co-administration of voglibose and vildagliptin expecting it to be beneficial by enhancing the peptide GLP-1 activity which in turn increases insulin secretion while decreasing that of glucagon in response to rise in plasma glucose.

Methods: Healthy male wistar rats weighing 150-250 grams were taken for this study. The animals were divided into five groups, six animals in each group. These groups were normal control, diabetic control, vildagliptin treated, voglibose treated and by vildagliptin and voglibose (co-administered) treated group diabetic rats. Diabetes was induced by freshly prepared nicotinamide followed by streptozotocin intraperitoneal injection. The fasting blood samples were determined by glucose oxidase method. One way ANOVA test was used to compare the effect of drugs on different group.

Results: Fasting blood glucose in normal control was found static. Diabetic rats fasting blood glucose level subsequently increased in different weeks. The animal treated by vildagliptin and voglibose orally has a better control of FBS in comparison to diabetic control group. The animal treated by co-administration of vildagliptin and voglibose had a better effect than vildagliptin treated group and voglibose treated animal.

Conclusions: Vildagliptin and voglibose are effective in lowering blood glucose level in albino diabetic rats but their combination has potentiating effect.


Keywords


Voglibose, Vildagliptin, Nicotinamide, Streptozotocin

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