Association of proton pump inhibitors with renal dysfunction: a cross-sectional study


  • Mamata Singh Department of Pharmacology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Ritu Bala Department of Pharmacology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Amit Jain Department of Pharmacology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Harminder Singh Department of Pharmacology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India
  • Ajay Prakash Department of Anaesthesia and Critical Care, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India



Proton pump inhibitors, Renal dysfunction, Serum creatinine, Estimated glomerular filtration rate


Background: Proton pump inhibitors are the most frequently prescribed class of medications for prescription and over-the-counter, and the data suggest that comorbidities, polypharmacy, self-medication, no clear indications and duration beyond the recommended guidelines PPIs use are associated with renal dysfunction. Aim was to study the proportion of renal dysfunction among patients using oral PPIs and determine the association between the duration of oral PPIs use and the severity of renal dysfunction.

Methods: The data collection of 250 patients was done at the time of contact, which included demographic profiles, complete medical history, physical examination, and laboratory investigation in this study. For analysis, name of oral PPIs used, duration and dosage of oral PPIs therapy, laboratory values of serum blood urea, serum creatinine, eGFR, and serum electrolytes parameters have been considered.

Results: Amongst 250 patients with PPIs used for a week, 23 patients showed mildly reduced kidney function (p=0.000), PPIs used for >1 to 2 weeks, 29 patients showed grade 2 kidney function (p=0.001), while PPIs used for >2-3 weeks only two patients showed grade 3 kidney function (p=0.44). Patients aged >50 years in all groups showed grade 2 renal function, regardless of the duration of PPIs use. Increasing age, males, rural, smoking, and alcoholics were the risk factors for renal dysfunction. PPIs use significantly impacts eGFR.

Conclusions: Collectively, this study found a significant association between PPIs use and renal dysfunction. PPIs used for >2 weeks in elderly patients have shown a 4−fold increased risk of developing renal dysfunction.


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How to Cite

Singh, M., Bala, R., Jain, A., Singh, H., & Prakash, A. (2023). Association of proton pump inhibitors with renal dysfunction: a cross-sectional study. International Journal of Basic & Clinical Pharmacology, 12(5), 699–705.



Original Research Articles