Study of anti-inflammatory effect of simvastatin in rats


  • Ranga Satya Venkatesh Department of Pharmacology, Drug store officer, Central Drug store, Andhra Pradesh, India
  • Lakshmi Deepika Patchva Department of Pharmacology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, chinnaoutpalli, Andhra Pradesh, India
  • Singamma Muppa Department of Pharmacology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, chinnaoutpalli, Andhra Pradesh, India



Simvastatin, Diclofenac sodium, Normal saline, Carrageenan, Plethysmometer


Background: Inflammation is a complex reaction in tissues that consists mainly of response of blood vessels and leukocytes. Simvastatin is a hypolipedemic drug belonging to the class of statins. Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate limiting enzyme in cholesterol synthesis, are widely prescribed for the treatment of hyperlipedemia. This study was conducted to evaluate the anti-inflammatory activity of simvastatin in albino rats using digital plethysmometer.

Methods: Male wistar albino rats weighing between 200-250 gm were selected for the study and rats were randomly divided into groups (control, standard, and test). The anti-inflammatory activity was evaluated by using carrageenan induced paw edema volume by using digital plethysmometer. Control group rats were administered 0.2 ml of normal saline, whereas, test group rats were administered simvastatin 40 mg and standard group diclofenac 50mg as single dose half an hour before injecting 0.1 ml of 1% carrageenan to the sub-plantar region of hind paw of rat. The paw edema of each rat was measured at 0 hour and after 3 hours.

Results: At a dose of 40 mg Simvastatin showed anti-inflammatory effect which is statically highly significant.

Conclusions: However, the above preclinical experiments only give us an idea about the anti-inflammatory activity, but large scale clinical trials are necessary for final assessment.


Kumar V, Abbas AK, Nelson F, Richard NM. Acute and chronic inflammation. Robbins basic pathology, 8th edition; WB Saunders Co; 2007:31-58.

Goodman and Gillman, Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of Gout, chapter 34, The Pharmacological basis of Therapeutics, 12th edition, The Pharmacological basis of therapeutics,12th edition, The Mac Graw Hill companies inc; 2011:986-987.

Tripathi KD. Hypolipaedimic drugs and plasma expanders, Chapter-45. Essential of Medical Pharmacology, 7th edition. Jaypee brother publishers; 2013:638.

Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89-118.

Evans M, Roberts A, Davies S, Rees A. Medical lipid-regulating therapy: current evidence, ongoing trials and future developments. Drugs. 2004;64:1181-96.

Srivastava K. Drugs for dyslipideamia, section 5, a complete textbook for medical pharmacology volume 1, 1st edition, Avichal Publishing company; 2012:327.

Anderson WAD. Inflammation and healing. pathology, 9th Edition, C.V. Mosby co. 1990;1:67.

Di Rosa M, Sorrenttino L. Biological properties of carrageenan. J Pharma Pharmacol. 1972;89:102.

Gosh MN. Experimental pharmacology.5th edition. Hilton and company. Gosh S.K publisher; 2007:120-123.




How to Cite

Venkatesh, R. S., Patchva, L. D., & Muppa, S. (2017). Study of anti-inflammatory effect of simvastatin in rats. International Journal of Basic & Clinical Pharmacology, 5(4), 1520–1523.



Original Research Articles