Drug utilization study of urinary tract infections in obstetrics and gynecology department

Anshu Gupta; Chanderpriya Agarwal; Karun Bhatti; Arvind Agarwal; Rosy Tayal

doi:10.18203/2319-2003.ijbcp20231131

Authors

Anshu Gupta Department of Pharmacology, MMIMSR, MMDU, Mullana, Ambala, Haryana, India
Chanderpriya Agarwal Department of Pharmacology, MMIMSR, MMDU, Mullana, Ambala, Haryana, India
Karun Bhatti Department of Pharmacology, MMIMSR, MMDU, Mullana, Ambala, Haryana, India
Arvind Agarwal Department of Pharmacology, MMIMSR, MMDU, Mullana, Ambala, Haryana, India
Rosy Tayal Department of Pharmacology, MMIMSR, MMDU, Mullana, Ambala, Haryana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20231131

Keywords:

Drug utilization, Urinary tract infection, Antimicrobial agents, Obstetrics and gynaecology department

Abstract

Background: The aim of study was to determine the utilization pattern of antimicrobial agents in obstetrics and gynaecology department. Antimicrobial agents are one of the most commonly used drugs word wide and has main contribution in human health system. UTI infection is one of the most widespread bacterial infections of genitourinary tract which can be treated by AMAs. The main aim of this study is; to identify the pattern of drug utilisation of antimicrobials in prescriptions, to analyse the utilisation of different classes of drugs and to identify the outcome of the treatment.

Methods: This prospective, observational and analytical study was conducted in patients of obstetrics and gynaecology department of MMIMSR, Mullana after obtaining approval from institutional ethical committee. Demographic data, medical history, prescribed treatment details (drug name, dose, frequency, dosage form etc) and diagnosis, type of UTI, laboratory investigations and outcome of treatment was evaluated.

Results: A total 242 female patients were registered, out of which 200 were included in the study as 42 were dropouts. Majority of female patients were belonging to the age group of 18-37 (63%). Most of the female patients had uncomplicated UTI 188 (94%) (p value=0.35), 186 (93%) had significant pyuria and 64 (32%) had urine culture positive (p value= 0.01). Burning micturation and frequency were the most common symptoms observed in 146 (73%). In the study 67(33.5%) females were pregnant and 133 (66.5%) were non pregnant (p value= 0.01). Out of 200 patients 64 (32%) had positive urine cultures and 136 (68%) had negative urine culture reports. E. coli 28 (14%) was the most common bacteria isolated followed by Klebsiella 16 (8%). Average number of drugs prescribed per prescription to non-pregnant was 3.97 and to pregnant were 4.67. In majority of prescriptions, the drugs were prescribed by oral routes (51%) and most of the drugs prescribed were generic (57%). Most of the patients (93%) were recovered from UTIs in 5-7 days of treatment.

Conclusions: Our study concluded that the uses of AMAs for UTI were found to be rational and according to the causative organism and susceptibility pattern.

Metrics

Metrics Loading ...

References

Chaudhary MK, Barai L, Shrestha M, Sen R, Kandel S. Utilization of antimicrobials by gynaecology and obstetrics department of crimson hospital. Int J Res Pharm Biomed. 2020;9(7):1695-703.

Agarwal CP, Gupta A, Walia R, Kumar N. Utilization pattern of drugs in expecting mothers visiting obstetrics and gynaecology in rural tertiary care center. Int J Med Sci Innovate Res. 2018;3(5):183-9.

Srivastava SK, Srivastava R. Pharmacology for MBBS. India: Avichal publishing company; 2021: 566.

Prakasam Arul KC, Kumar Dileesh KG, Vijayan M. A Cross Sectional Study on Distribution of Urinary Tract Infection and Their Antibiotic Utilization Pattern in Kerala. Int J Res Pharm Biomed Sci. 2012;3(3):1125-30.

Johnson LW. Family medicine principles and practice part 2. Urinary Tract Infect. 2020.

Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Larry JJ, Loscalzo J. Harrison’s Principles of Internal Medicine 17th edn. USA: Mc Graw Hill companies; 2008:1820.

Mishra R, Pradeep. Drug utilisation study of urinary tract infections in medicine department in a tertiary care hospital. J Evol Med Dent Sci. 2014;3(63):13804-16.

Fatima E, Anwar A, Dudeja M, Akhtar M, Najmi KA. Drug utilisation pattern and adverse drug reaction monitoring in urinary tract infection patients in a tertiary care hospital. J Drug Delivery Therap. 2015; 5(6):23-30.

Mahesh E, Ramesh D, Indumathi VA, Punith K, Kirthi R, Anupama HA. Complicated urinary tract infection in a tertiary care centre in south India. Alamen J Med Sci. 2010;3(2):120-7.

Prakasam KCA, Kumar KG, Dileesh, Vijayan M. A cross sectional study on distribution of urinary tract infection and their antibiotic utilisation pattern in Kerala. Int J Res Pharm Biomed Sci. 2012;3(3):1125-30.

Chowta NM. Drug utilisation pattern in urinary tract infections. A retrospective study. Insta Sci J Med Sci Clin Res. 2011;1(1):13-9.

Singh P, Singh VK, Nazam R, Khan FA, Matreja PS. Antimicrobial usage in obstetrics and gynaecology department of a tertiary care teaching, Int J Pharmacol Res. 2017;7(3):77-80.