Prescription pattern in ischemic heart disease inpatients at B. P. Koirala Institute of Health Sciences: a cross sectional study

Authors

  • Dillisher Rai Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Gajendra Prasad Rauniar Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Prashant Shah Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Dipesh R. Pandey Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Namita K. Mandal Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Deependra P. Sarraf Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20230200

Keywords:

Antiplatelet, Drug utilization, Hypolipidemics, IHD

Abstract

Background: Drug utilization pattern studies seek to screen, evaluate and suggest appropriate modifications in prescription practices. It would help to make patient care rational and cost effective. Objective was to analyze the drug prescribing pattern for treatment of ischemic heart disease (IHD).

Methods: A prospective cross-sectional observational study was conducted in patients of IHD admitted in intensive coronary care unit and medicine ward for the period of six months. Data were collected in preformed case record form. The data were analyzed for drug use indicators, demographic parameters, morbidities, pattern of drug use using Microsoft excel 2010.

Results: A total of 145 patients were enrolled out of that 89 (61.38%) were males. The mean age was 60.01±12.71 years and majority (26.89%) belonged to age group of 61-70 years. A total of 1208 drugs were prescribed in 145 patients. Most frequently prescribed drugs were antiplatelet group of drugs 100% encounters, followed by hypo-lipidemics (98.62%). Average number of drugs per encounter was 8.33 and percentage of drugs prescribed by generic name was 5.04%. 

Conclusions: IHD was more common in males than females. The most commonly prescribed drug classes were anti-platelet drugs followed by hypolipidemic agents.

Metrics

Metrics Loading ...

References

Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2013;168(2):934-45.

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095-128.

Global status report on noncommunicable diseases 2014, World Health Organization. Available at: https://apps.who.int/iris/bitstream/handle/10665/148114/9789241564854_eng.pdf. Accessed on 1 December, 2022.

Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480-6.

Bhandari GP, Angdembe MR, Dhimal M, Neupane S, Bhusal C. State of non-communicable diseases in Nepal. BMC Public Health. 2014;14:23.

Ghimire S, Mishra SR, Baral BK, Dhimal M, Callahan KE, Bista B et al. Noncommunicable disease risk factors among older adults aged 60-69 years in Nepal: findings from the STEPS survey 2013. J Hum Hypertens. 2019;33(8):602-12.

Vaidya A, Pokharel PK, Nagesh S, Karki P, Kumar S, Majhi S. Prevalence of coronary heart disease in the urban adult males of eastern Nepal: a population-based analytical cross-sectional study. Indian Heart J. 2009;61(4):341-7.

Maskey A, Sayami A, Pandey S. Coronary artery disease: an emerging epidemic in NEPAL. JNMA. 2003;42(146):122-4.

The Selection of Essential Drugs. WHO Technical Report, Volume 615, Geneva: WHO; 1977:36. Available at https://apps.who.int/iris/bitstream/ handle/10665/41272/WHO_TRS_615.pdf. Accessed on 1 December, 2022.

Hasmnis AA, Patil SS, Narayan KA, Rashid AK, Mohanty BK. Drug utilization study for acute illnesses in village Banggol, Malaysia; The findings of a household survey. Al Ameen J Med Sci. 2010;3:165-8.

Shankar PR, Upadhyay DK, Subish P, Dubey AK, Mishra P. Prescribing patterns among paediatric inpatients in a teaching hospital in western Nepal. Singapore Med J. 2006;47(4):261-5.

Enwere OO, Falade CO, Salako BL. Drug prescribing pattern at the medical outpatient clinic of a tertiary hospital in southwestern Nigeria. Pharmacoepidemiol Drug Saf. 2007;16(11):1244-9.

Yilma Z, Liben M. Assessment of drug prescription pattern in Mekelle General Hospital, Mekelle, Ethiopia, using World Health Organization Prescribing indicators. Biomed Res Int. 2020;2020:3809157.

Sujana PN, Kumanan R, Sambasiva RA. Prescribing pattern in coronary artery disease of Indian railway hospital. Int J of Allied Med Sci and Clin Res. 2017;5(2):487-513.

Kamath A, Shanbhag T, Shenoy S, Ramesh S. A retrospective study of the drug prescribing pattern in acute myocardial infarction. Ind J Pharmacol. 2008;40:S60-61.

Tasneem S, Fouzia N. Drug utilization study in ischemic heart diseases associated with diabetes and hypertension. Int J Pharma and Bio Sci. 2010;1(3):1-4.

Shruthi Dawalji, Venkateshwarlu K, Sridhar Thota, Praveen Kumar Venisetty, Raj Kumar Venisetty. Prescribing pattern in coronary artery disease: a prospective study. IJPRR. 2014;3(3):24-33.

Acartürk E, Cayli M, Akpinar O, Attila G, Demir M. Relation between age and gender differences in plasma triglyceride concentrations and coronary artery disease in Southern Turkey. Clin Chimica Acta. 2004;339(1):123-8.

Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502.

Jorg M, Giorgio N, Roger D, Christiane G, Felix G, Ferenc F. National survey on prescription of cardiovascular drugs among outpatients with coronary artery disease in Switzerland. Swiss Med Wkly. 2003;133:88-92.

Datta S, Sharma C. Prescribing pattern of antihypertensives in patients having co-morbid ischemic heart disease: study in a tertiary care hospital. J Pharmacy Res. 2010;3:2142-4.

Battu Rakesh, BS Suresha, Jaladi Himaja, Emilda T Joy. Assessment of prescribing pattern in coronary artery disease. Int J of Allied Med Sci and Clin Res. 2016; 4(4):698-715.

Everly MJ, Heaton PC, Cluxton RJ Jr. Beta-blocker underuse in secondary prevention of myocardial infarction. Ann Pharmacother. 2004;38(2):286-93.

Sreedevi K, Rao VJ, Fareedullah MD, Vijayakumar S. A study on prescription pattern of statins in cardiovascular disease. Der Pharmacia Lettre. 2011;3:393-6.

Mohan V, Venkatraman JV, Pradeepa R. Epidemiology of cardiovascular disease in type 2 diabetes: The Indian scenario. J Diabetes Sci Technol. 2010;4:158-70.

Ofori-Asenso R, Brhlikova P, Pollock AM. Prescribing indicators at primary health care centers within the WHO African region: A systematic analysis (1995-2015). BMC Public Heal. 2016;16:724.

Kesselheim AS, Eddings W, Raj T, Campbell EG, Franklin JM, Ross KM et al. Physicians' trust in the FDA's use of product-specific pathways for generic drug approval. PLoS One. 2016;11:e0163339.

Downloads

Published

2023-01-25

How to Cite

Rai, D., Rauniar, G. P., Shah, P., Pandey, D. R., Mandal, N. K., & Sarraf, D. P. (2023). Prescription pattern in ischemic heart disease inpatients at B. P. Koirala Institute of Health Sciences: a cross sectional study. International Journal of Basic & Clinical Pharmacology, 12(2), 148–152. https://doi.org/10.18203/2319-2003.ijbcp20230200

Issue

Section

Original Research Articles