Recent advancement in drugs of Alzheimer's disease

Authors

  • Syed Rubina Zaidi SGRR School of Pharmaceutical Sciences, Dehradun, Uttarakhand, India
  • Ashutosh Badola SGRR School of Pharmaceutical Sciences, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20223367

Keywords:

Alzheimer disease, Neuro-degeneration, Tau-protein, β-amyloid protein, Presymptomatic, Clinical trials

Abstract

Alzheimer's disease (AD), a multifaceted neurological ailment that progresses over time, is the most common cause of dementia in older people. Intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contribute to senile plaques on a pathological level. AD symptoms vary depending on the stage of the disease. Depending on the severity of cognitive impairment, AD is classified as preclinical or presymptomatic, mild, or dementia-stage. In addition, the condition is influenced by a number of risk factors, including advancing age, hereditary factors, head injuries, vascular diseases, infections, and environmental variables. There are currently only two types of licenced medications to treat AD: inhibitors of the cholinesterase enzyme such as donepezil, rivastigmine, galantamine and antagonists of N-methyl d-aspartate (NMDA) such as memantine, both of which are only effective in treating the symptoms of the disease and do not cure or prevent it.

Author Biography

Syed Rubina Zaidi, SGRR School of Pharmaceutical Sciences, Dehradun, Uttarakhand, India

I am pursuing doctor of pharmacy, i am in 5th year

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Published

2022-12-26

How to Cite

Zaidi, S. R., & Badola, A. (2022). Recent advancement in drugs of Alzheimer’s disease. International Journal of Basic & Clinical Pharmacology, 12(1), 125–133. https://doi.org/10.18203/2319-2003.ijbcp20223367

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Section

Review Articles