Real-world utilization and acceptance of biosimilar bevacizumab in metastatic colorectal cancer in India


  • Deepak Bunger Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
  • Anil Rajani Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
  • Lav Patel Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India
  • Shreekant Sharma Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India



Bevacizumab, Biosimilar, Metastatic, Colorectal, Cancer


Background: To describe the patient characteristics and usage pattern of biosimilar bevacizumab for the treatment of metastatic colorectal cancer (mCRC) in India.

Methods: This real-world, retrospective analysis included adult patients receiving biosimilar bevacizumab between April 2021 and March 2022.

Results: A total of 1125 patients with mCRC who received biosimilar bevacizumab-based chemotherapy were included. The mean age at diagnosis was 57.8 years. Majority of the patients were males (71%) and belonged to the age groups of 41-76 years. The primary tumor site was right colon (52.6%) followed by left colon (29.2%) and rectum (17.3%), and tumor grade was reported as high in most (88.7%) of the patients. Majority of the patients received biosimilar bevacizumab-based chemotherapy as first-line therapy (61.3%), followed by second-line (31.9%) and third-line therapy (6.8%). In combination with biosimilar bevacizumab, FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) was the most commonly administered chemotherapy regimen (42.9%), followed by CAPOX (capecitabine and oxaliplatin, 26.5%) and FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan, 22.8%).

Conclusions: Biosimilar bevacizumab-based chemotherapy is being widely used in real‑world clinical setting in India for the management of patients with mCRC.


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How to Cite

Bunger, D., Rajani, A., Patel, L., & Sharma, S. (2022). Real-world utilization and acceptance of biosimilar bevacizumab in metastatic colorectal cancer in India. International Journal of Basic & Clinical Pharmacology, 11(6), 564–567.



Original Research Articles