Potential anticancer activity of some medicinal plants in vitro and in vivo study
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20222757Keywords:
Tumors, Indianorigin, AnticancerMedicinalPlants, invitroandinvivoprocesses.Abstract
The public health burden caused by cancer is significant in both developing and developed nations. The ability of biological, chemical, or synthetic substances to prevent, inhibit, or stop the progression of carcinogenic is known as anticancer activity. To treat the condition, several synthetic drugs are utilized, however because of their toxicity, research is now being done to examine chemotherapeutic medicines produced from plants. A review of several in vivo and in vitro techniques for determining the anticancer activities of natural compounds from medicinal plants has thus been undertaken. In this study, 50 Indian anticancer medicinal plants from 35 families are presented, together with comprehensive data on the parts and extracts utilized, the model type employed, the cancer cell line types that were tested, etc. These plants are still utilized to treat numerous tumor forms, including lymphoma, sarcoma, leukemia, and carcinoma. All of plants are likely candidates for in vivo research since they have strong anticancer action in vitro.
References
GuptaVK,SharmaSK.Plantsasnaturalantioxidants.NatProdRad2006; 17: 326-334.
SivakumarR, BalachandranP,GovindarajanR.Cancer-anayurvedicperspective.PharmacolRes2005;51:19-30.
ParinithaM,SrinivasaBH,ShivannaMB.Medicinal plant wealth of local communities insome villages in Shimoga distinct of Karnataka.IndiaJEthnopharmacol2005;98:307-312.
SamuelssonG.Drugsofnaturalorigin.Atextbook of pharmacognosy. 4th ed., Stockholm,SwedishPharmaceuticalPress.1999
KrishnamurthiK.Screeningofnaturalproductsforanticancerandantidiabeticproperties.HealthAdministrator2007;1&2:69-75.
Divisi D, Di TS, Salvemini S, et al.,Diet andcancer.ActaBiomed2006;77:118-123.
MohammadS.Anticanceragentsfrommedicinalplants.BangladeshJPharmacol2006;1:35-41.
HartwellJL.Plantsare usedagainstcancer.Asurvey.QuartermanPublications,Lawrence;1982.
Kinghorn AD, Farnsworth NR, Soejarto DD, etal.,Novel strategies for the discovery of plant-derived anticancer agents. Pharmaceutic Biol2003;41:53-67.
Surh YJ. Cancer chemoprevention with dietaryphytochemicals.NatureRevCancer2003;3:768-780.
Cardellina JH, Gustafson KR, Beutler JA, et al.,National cancer institute intramural researchon human immunodeficiency virus inhibitoryandantitumorplantnaturalproducts.Human
MedicinalAgentsfromPlants;1993;15pp.218-227.
NairPKR,MelnickbSJ,WnukcSF,etal.,Isolation and characterization of an anticancercatecholcompoundfromSemecarpusanacardium. J Ethnopharmacol 2009; 122: 450-456.
TanG, Gyllenhaal C, Soejarto DD. Biodiversity asasourceofanticancerdrugs.CurrDrugTargets2006;7: 265-277.
Cragg GM, Newman DJ. Antineoplastic agentsfrom natural sources: achievements and futuredirections. ExpetOpinInvestig Drugs 2000; 9:1-15.
Pezzuto JM. Plants derived anticancer agents.BiochemPharmacol 1997;53:121-133.
NewmanDJ,CraggGM,SnaderKM.Naturalproductsassourcesofnewdrugsovertheperiod 1981-2002. J Nat Prod 2003; 66: 1022-1037.
UnnikrishnanMC,RamadasanK.Cytotoxicityofextracts of spices to cultured cells. Nutr Cancer1998;11:251-257.
RussoA,PiovanoM,LombardoL,etal.,Pannarin inhibits cell growth and induces celldeath in human prostate carcinoma DU- 145cells.Anti-CancerDrugs2006;17:1163-1169.
MossmanT.Rapidcolorimetricassayforcellulargrowthandsurvival:applicationtoproliferation and cytotoxicity assays. J ImmunolMethods1983;65:55-63.
EconomouMA,AnderssonS,VasilcanuD,etal.,Oralpicropodophyllin(PPP)iswelltoleratedinvivoandinhibitsIGF-1Rexpressionandgrowthofuvealmelanoma.ActaOphthalmologica2008;86:35-41.
SkehanP, StorengR, ScudieroD, et al., Newcolorimetric cytotoxicity assay for anticancer-drugscreening.JNatlCancerInst 1990; 82:1107-1112.
DeviPU,RaoBSS,SolomonFE.Effectofplumbaginontheradiation-inducedcytogeneticand cell cycle changes in mouse Ehrlich ascitescarcinoma in vivo. Indian J Exp Biol 1998; 36:891-895.
AbdullaevFI.Plant-derivedagentsagainstcancer. In: Gupta, S. K., editor. Pharmacologyand therapeutics in the new millennium. NarosaPublishing House: New Delhi, India, 2001; p.345-354.
CraggGM,NewmanDJ.Plantsasa sourceofanticancer agents. J Ethnopharmacol 2005; 100:72-79.
AlagesaboopathiC.StudiesoncytotoxicityandantitumorscreeningofredandwhiteformsofAbrusprecatoriusL.AfrJBiotechnol2008;7:3984-3988.
SubbaRVV,SirsiM.EffectofAbrusprecatorius
L. on experimental tumors. Cancer Res 1969;29:1447-1451.
Jagetia GC, Baliga MS. Evaluation of anticanceractivityofthealkaloidfractionofAlstoniascholaris in vitro andin vivo. Phytother Res2006;20:103-109.
KulkarniMP,JuvekarAR.EffectofAlstoniascholaris Linn. on stress and cognition in mice.IndianJExpBiol2008;47:47-52.
SharmaPR,MondheDM,MuthiahS,etal.,AnticanceractivityofessentialoilfromCymbopogon flexuosus. Chemico-Biol Interact2009;179:160-168.
MakkerPN,TaitL,ShekharMPV,etal.,InhibitionofbreasttumorgrowthandangiogenesisbyamedicinalherbOcimumgratissimum.IntJCancer 2007; 121:884-894.
AjithTA,JanardhananKK.Antioxidantandantihepatotoxic activities of Phellinus rimosus(Berk) Pilat. J Ethnopharmacol 2002; 81: 387-391.
AjithTA,JanardhananKK.Cytotoxicandantitumoractivitiesofapolyporemacrofungus,PhellinusrimosusPilat.JEthnopharmacol2003;84:157-162.
Malik A, Afaq F, Sarfaraz S, et al., Pomegranatefruitjuiceforchemopreventionandchemotherapyofprostatecancer.ProcNatlAcadSci2005;102:14813-14818.
ShuklaY,PrasadS,TripathiC,etal.,Invitroandin vivomodulation of testosterone mediatedalterationsinapoptosis-relatedproteinsby[6]-gingerol. Mol Nutr Food Res 2007; 51: 1492-1402.
StoilovaI,KrastanovA,StoyanovaA,etal.,Antioxidantactivityofagingerextract(Zingiberofficinale).FoodChem2007;102:764-770.
GuevaraAP,VargasC,SakuraiH,etal.,AnantitumorpromoterfromMoringaoleiferaLam.MutationRes1999;440:181-188.
VermaAR,VijayakumarM,MathelaCS,etal.,Invitroandinvivoantioxidantpropertiesofdifferent fractions of Moringa oleifera leaves.FoodChemToxicol2009;47:2196-2201.
EjazS,WoongLC,EjazA.Extractofgarlic(Allium sativum) in cancer chemoprevention.ExpOncol2003;25:93-97.
Balasenthila S, Ramachandranb CR, Naginia S.Preventionof4-nitroquinoline1-oxide-inducedrat tongue carcinogenesis by garlic. Fitoterapia2001;72:524-531.
Agrawal A, Sharma M, Rai S, et al., The effect ofthe aqueous extract of the roots of Asparagusracemosusonhepatocarcinogenesisinitiatedby diethyl nitrosamine. Phytother Res 2008; 22:1175-1182.
Kamata JP, Boloora KK, Devasagayam TPA, etal.,AntioxidantpropertiesofAsparagusracemosusagainstdamageinducedbyγ-radiationinratlivermitochondria.JEthnopharmacol2000;71:425-435.
Sayed EA, Cordell GA. Catharanthus alkaloidsatharanthamine,anewantitumorbisindolealkaloid from Catharanthus roseus. J Nat Prod1981;44:289-293.
JohnsonIS,WrightHF,SvobodaGH,etal.,Antitumor principles derived from Vinca roseaL.CancerRes 1960;20: 1016-1022.
JaleelC,GopiAR,ManivannanP,etal.,Antioxidantpotentialandindolealkaloidprofilevariationswithwaterdeficitsalongdifferentpartsoftwo varietiesofCatharanthusroseus. Colloids Surf B Biointerfaces2008; 62:312-318.
Raj Kapoor B, Jayakar B, Murugesh N. Antitumoractivity of Indigofera aspalathoides on Ehrlichascites carcinoma in mice. Indian J Pharmacol2004;36:38-40.
BakassoS,MedaLA,LamienCE,etal.,Polyphenol contents and antioxidant activitiesoffiveIndigoferaspecies(Fabaceae)fromBurkinaFaso.PakistanJBiolSci2008;11:1429-1435.
Rajendran P, Ekambaram G, Sakthisekaran D.Effectofmangiferinonbenzo(a)pyrene-inducedlungcarcinogenesisinexperimentalSwissalbinomice.NatProdRes.,2008;22:672-680.
JoharDA,ShinwariN,ArifJ,etal.,RoleofNigella sativa and a number of its antioxidantconstituentstowardsAzoxymethane-inducedgenotoxiceffectsandcoloncancerinrats.PhytotherRes2008;22:1311-1323.
SwamySMK,TanBKH.CytotoxicandimmunopotentiatingeffectsofethanolicextractofNigellasativaL.seeds.JEthnopharmacol2000;70:1-7.
Kavitha K, Manoharan S. Anticarcinogenic andanti-lipid peroxidativeeffectsofTephrosiapurpurea L. in 7,12-dimethylbenz(a)anthracene(DMBA)inducedhamsterbuccalpouchcarcinoma. Indian J Pharmacol 2006; 38: 185-189.
RaoSK,RaoPS,RaoBN.Preliminaryinvestigation of the radiosensitizing activity ofguduchi(Tinosporacordifolia)intumor bearing mice.Phytother Res., 2008; 22: 1482-1489.
Prince PSM, Menon VP. Antioxidant activity ofTinosporacordifoliarootsinexperimentaldiabetes.JEthnopharmacol1999;65:277-281.
Padmavathi B, Rath PC, Rao AR, et al., Roots ofWithaniasomniferainhibitforestomachandskin carcinogenesis in mice.Adv Access Publi2005;2:99-105.
VisavadiyaNP,NarasimhacharyaAVRL.Hypocholesteremic and antioxidant effects ofWithania somnifera (Dunal) inhypercholesteremic rats. Phytomedicine 2007;14:136-142.
Yoshida T,ChouT,NittaA,etal.,WoodfordinC,a Micro-ring hydrolyzable tannin dimer withantitumor activity and accompanying dimmersfromWoodfordiafruticosaflowers.ChemPharmBull1990;38:1211-1217.
KumaraswamyMV,SatishS.FreeradicalscavengingactivityandlipoxygenaseinhibitionofWoodfordiafructicosaKurzandBetulautilisWall.AfrJBiotechnol2008;7:2013-2016.
GangarSC,KoulA.Azadirachtaindicamodulatescarcinogenbiotransformation andreduced glutathione at peri-initiation phase ofbenzo(a)pyrene-induced murine forestomachtumorigenesis. Phytother Res 2008; 22: 1229-1238.
KumarS,SureshPK,VijayababuMR,etal.,Anticancer effects of ethanolic neem leaf extracton prostate cancer cell line. J Ethnopharmacol2006;105:246-250.
KapadiaGJ,TokudaH,KonoshimaT,etal.,Chemoprevention of lung and skin cancer byBeta vulgaris root extract. Cancer Lett 1996;100:211-214.
JiratananT,LiuRH.Antioxidantactivityofprocessedtablebeets(Betavulgaris)andgreenbeans (Phaseolus vulgaris). J Agric Food Chem2004;52:2659-2670.
SultanaS,AhmedS,JahangirT.Emblicaofficinalisandhepatocarcinogenesis:AchemopreventivestudyinWistarrats.J.Ethnopharmacol2008;118:1-6.
AnilaL,VijayalakshmiNR.Antioxidantactionofflavonoids from Mangifera indica and Emblicaofficinalis in hypercholesterolemic rats. FoodChem2003;83:569-574.
Nam NH, Lee CW, Hong DH, et al., Antiinvasive,antiangiogenicandantitumoractivityofEphedra sinica extract. Phytother Res., 2003;17:70-76.
Rastogi S, Shukla Y, Paul BN, et al., ProtectiveeffectofOcimumsanctumon3-methylcholanthrene, 7,12-dimethylbenz(a)anthraceneandaflatoxinB1inducedskintumorigenesisinmice.ToxicolApplPharmacol.,2007;224:228-240.
CebovicT,SpasicS,PopovicM.CytotoxiceffectsoftheViscumalbumL.extractonEhrlichtumor cells in vivo. Phytother Res 2008; 22:1097-1103.
Ucar EO, Karagoz A, Arda N. Antioxidant activityof Viscum album ssp. album. Fitoterapia 2006;77:556-560.
HirotaM,SuttajitM,SuguriH,et al.,A newtumor promoter from the seed oil of JatrophacurcasL.,anintramoleculardiesterof12-Deoxy-16-hydroxyphorbol.CancerRes1988;48:5800-5804.
YanR,GaoS,YangW,et al.,Nickeltoxicityinducedantioxidantenzymeandphenylalanineammonia-lyase activities in Jatropha curcas L.cotyledons. Plant Soil Environ 2008; 54: 294-300.
Geethangili M, Rao YK, Fang S, et al., CytotoxicconstituentsfromAndrographispaniculatainducecellcyclearrestinjurkatcells.PhytotherRes2008;22:1336-1341.
Mondal S, Mondal NB, Mazumder UK. In vitrocytotoxicandhumanrecombinantcaspaseinhibitoryeffectof Annonareticulate leaves.IndianJPharmacol2007; 39:253-254.
BaskarR,RajeswariV,KumarTS.Invitroantioxidant studies in leaves of Annona species.IndianJExpBiol2007;45:480-485.
RohiniG,ShyamalaDCS.Bacopamonnieraextract induces apoptosis in murine sarcomacells.PhytotherRes2008;22:1595-1598.
TomosakaH,ChinY,SalimAA,etal.,Antioxidantandcytoprotectivecompoundsfrom Berberis vulgaris. Phytother Res 2008; 22:979-981.
SundararajanP,DeyA,SmithA,etal.,StudiesofanticancerandantipyreticactivityofBidenspilosa whole plant. Afr Health Sci 2006; 6: 27-30.
Abajo C, Boffill MA, Campo J, et al., In vitro studyoftheantioxidantandimmunomodulatoryactivity of aqueous infusion of Bidens pilosa. JEthnopharmacol2004;93:319-323.
Tannin-SpitzT, GrossmanS, DovratS, etal.,Growthinhibitoryactivityofcucurbitacinglucosides isolated from Citrullus colocynthisonhumanbreastcancercells.BiochemPharmacol2007;73:56-67.
SpitzTT,BergmanM,GrossmanS.Cucurbitacinglucosides:Antioxidantandfree-radicalscavengingactivities.BiochemBiophysResCommun2007;364:181-186.
AbdullaevFI.Cancerchemopreventiveandtumoricidal properties of Crocus sativus L. ExpBiolMed2002;227:20-25.
EscribanoJ, AlonsoG,Coca-PradosM, etal.,Crocin, safranal and picrocrocin from Crocussativus L. inhibit the growth of human cancercellsinvitro.CancerLett1996;100:23-30.
SinghR,GuptaAK.Antimicrobialandantitumoractivityofthefractionatedextractsofkalimusli(Curculigoorchioides). Int J Green Pharm 2008;2:34-36.
Venukumar MR, Latha MS. Antioxidant activityof Curculigoorchioides in carbon tetrachloride-inducedhepatopathyinrats.IndianJClinBiochem2002;17:80-87.
Prasad KN, Ashok G, Raghu C, et al., In vitrocytotoxic properties of Ipomoea aquatica leaf.IndianJPharmacol2005;37:397-398.
Raghu C, Ashok G, Dhanaraj SA, et al., In vitrocytotoxicactivityofLantanacamaraLinn.IndianJPharmacol2004;36:93-95.
SimardF,LegaultJ,LavoieS,etal.,Isolationandidentification of cytotoxic compounds from thewood of Pinus resinosa. Phytother Res 2008;22:919-922.
Pietarinen SP, Willfor SM, Ahotupa MO, et al.,Knotwoodandbarkextracts:strongantioxidants from waste materials. J Wood Sci2006;52:436-444.
KaurP,SinghB,KumarS,etal.,Invitroevaluation of free radical scavenging activity ofRubia cordifolia L. J Chinese Clin Med 2008; 3:278-284.
SonJK,JungSJ,JungJH,etal.,Anticancerconstituents from the roots of Rubia cordifoliaL.ChemPharmBull2008;56:213-216.
ChakrabortyS,RoyM,TaraphdarAK,etal.,CytotoxiceffectofrootextractofTiliacoraracemosa and oil of Semecarpus anacardiumnut in human tumor cells. Phytother Res 2004;18:595-600.
Ali H, ChowdhuryAKA, Rahman AKM, etal.,PachypodolaflavonolfromtheleavesofCalycopteris floribunda, inhibits the growth ofCaCo-2coloncancercelllineinvitro.PhytotherRes2008;22:1684-1687.
Sharma PR, Shanmugavel M, Saxena AK, et al.,Induction of apoptosis by a synergistic lignancompositionfromCedrusdeodarainhumancancercells.PhytotherRes2008;22:1587-1594.
Tiwari AK, Srinivas PV, Kumar SP, et al., FreeradicalscavengingactivecomponentsfromCedrus deodara. J Agric Food Chem 2001; 49:4642-4645.
LeeYK,LeeWS,HwangJT,etal.,Curcuminexertsanti-differentiationeffectthroughAMPKα-PPAR-γin3T3-L1adipocytesandantiproliferatoryeffect through AMPKα-COX-2in cancer cells. J Agric Food Chem., 2009; 57:305-310.
HsuY,WengH,LinS,etal.,Curcuminoids-Cellularuptakebyhumanprimarycoloncancercells as quantitated by a sensitive HPLC assayanditsrelationwiththeinhibitionofproliferation and apoptosis. J Agric Food Chem2007;55:8213-8222.
Cao S, Norris A, Wisse JH, et al., Ipomoeassin F,a new cytotoxic macrocyclic glycoresin from theleaves of Ipomoea squamosa from the Surinamerainforest.NatProdRes2007;21:872-876.
Wu SB, Ji YP, Zhu JJ, et al., Steroids from theleaves ofChineseMeliaazedarachandtheircytotoxiceffects onhumancancercelllines.Steroids2009;74:761-765.
Szewczuk VD, Mongelli ER, Pomilio AB. In vitro,anthelminticactivityofMeliaazedarachnaturalized in Argentina. Phytother Res 2006;20:993-996.
KamiyaK,HamabeW,TokuyamaS,etal., InhibitoryeffectofanthraquinonesisolatedfromtheMorindacitrifoliaroot onanimalA,B, and Y families of DNA polymerases and humancancercellproliferation.FoodChem2009;118:725-730.
AnekpankulT,GotoM,SasakiM,etal.,Extractionofanticancerdamnacanthalfromroots of Morindacitrifolia by subcritical water.SepPurifTechnol2007;55:343-349.
Verma M, Singh SK, Bhushan S, et al., In vitrocytotoxic potential of Polyalthia longifolia onhumancancercelllinesandinductionofapoptosisthroughmitochondrial-dependentpathway in HL-60 cells. Chemico-Biol Interact2008;171:45-56.
Chen KC, Hsieh CL, Peng CC, et al., Brain-derived metastatic prostate cancer DU-145 cellsareeffectivelyinhibitedinvitrobyguava(Psidium gujava L.) leaf extracts. Nutr Cancer2007;58:93-106.
JoshiCG,GopalM,KumariNS.Antitumor activity of hexane and ethyl acetateextractsofTragiainvolucrata.InternationalJournalofCancerResearch2011; 7: 267-277.
ReddyDB,ReddyTCM,JyotsnaG,etal.,Chebulagicacid,aCOX-LOXdualinhibitorisolated from the fruits of Terminalia chebulaRetz.,inducesapoptosisinCOLO-205cellline.JEthnopharmacol2009; 124:506-512.