Lipid profile improving effect of Coriandrum sativum seed extract in rats


  • Zeinab M. Hassan Department of Pharmacology, Benha University Faculty of Veterinary Medicine, 13736 Moshtohor, Egypt
  • Afaf A. Afify Department of Pharmacology, Benha University Faculty of Veterinary Medicine, 13736 Moshtohor, Egypt
  • Faten I. Elsayed Department of Pharmacology, Benha University Faculty of Veterinary Medicine, 13736 Moshtohor, Egypt
  • AbuBakr M. El-Mahmoudy Department of Pharmacology, Benha University Faculty of Veterinary Medicine, 13736 Moshtohor, Egypt



Coriander sativum, Hyperlipidaemia, Phytoanalysis, Seed extract


Background: Hyperlipidaemia is a common disease in middle-aged and elderly people. It has received attention, as it indirectly affects the normal metabolism, blood viscosity and vital organ functions. It is a risk factor for cardiovascular and cerebrovascular diseases. Therefore, the aim of the present study was to evaluate the possible antihyperlipidemic effect of Coriander sativum seed extract (CSSE) in rats fed on high-fat diet.

Methods: A parallel study design was adopted on 42 albino rats, divided randomly into 7 groups with different treatments. After a 6 week-experimental course, blood samples were collected and analysed for lipid and organ function parameters. Phytochemical analysis was conducted on the used seed extract to detect the active principles underlying its effects.

Results: CSSE (150 and 300 mg/kg, orally, once daily) along with a high-fat (1.5% cholesterol+1.5% coconut oil, in diet) diet resulted in a significant (p≤0.05) improvement in plasma lipid parameters, including, total cholesterol, triacyglycerols and lipoproteins, compared to the high-fat group. group. The extract significantly (p≤0.05) improved hepatic (total proteins, albumin, globulins, total conjugated and unconjugated bilirubins, AST, ALT, GGT), cardiac (CK-MB and troponin-I) and renal (urea, creatinine & uric acid) biomarkers. Phytoanalysis of CSSE revealed presence of phlobatannin and flavonoids. The protection % produced by small and large doses of CSSE were dose-dependent and parallel to those of the standard antihyperlipidemic rosuvastatin (2 mg/dl orally, daily).

Conclusions: These data indicate that CSSE has a marked antihyperlipidemic effect and could be a source for a promising nutraceutical antihyperlipidemic drug depending on its high phenolic and flavonoid content.


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How to Cite

Hassan, Z. M., Afify, A. A., Elsayed, F. I., & El-Mahmoudy, A. M. (2022). Lipid profile improving effect of Coriandrum sativum seed extract in rats. International Journal of Basic & Clinical Pharmacology, 11(5), 356–363.



Original Research Articles