A systematic review on metformin rational pharmacotherapeutics


  • Moumita Hazra Department of Pharmacology, Mamata Medical College, Telangana, India




Rational pharmacotherapeutics, Systematic review, Metformin


This systematic review of the different and wide-ranged studies on metformin rational pharmacotherapeutics was performed, for a better comprehension of multi-centre maintenance of rational pharmacotherapeutic aspects in the regular anti-diabetic treatment prescribed to the new type II diabetic patients. This systematic review contributed 3729 refined and relevant medical records, among total 4570 records obtained from the study databases search, thus providing a refined qualitatively synthesised conclusive medical research study literature, on metformin rational pharmacotherapeutics.

Author Biography

Moumita Hazra, Department of Pharmacology, Mamata Medical College, Telangana, India

1Associate Professor, Head of Department In Charge, Department of Pharmacology, Mamata Medical College and Hospitals, Telangana, India;

2Former Associate Professor, Head of Department In Charge, Department of Pharmacology, Rama Medical College Hospital and Research Centre, Rama University, Uttar Pradesh, India;

3Medical Director, Consultant Multi-Specialist Clinical Pharmacological Physician, Consultant Clinical Pathologist, Medical Superintendent, Medical Academics and Clinical Research Director, Dr. Moumita Hazra’s Polyclinic And Diagnostic Centre, Hazra Nursing Home, Hazra Polyclinic And Diagnostic Centre, Dr. Moumita Hazra’s Academic Centre, Dr. Moumita Hazra’s Educational Centre, West Bengal, India, World;

4Consultant Pathologist, Laboratory Supervisor, Mahuya Diagnostic Centre and Doctors’ Chamber, West Bengal, India.



Wright RW, Brand RA, Dunn W, Spindler KP. How to write a systematic review. Clin Orthop Relat Res. 2007;455:23-9.

Tawfik GM, Dila KAS, Mohamed MYF, Tam DNH, Kien ND, Ahmed AM, et al. A step by step guide for conducting a systematic review and meta-analysis with simulation data. Trop Med Health. 2019;47:46.

Palanisamy S, Yien ELH, Shi LW, Si LY, Qi SH, Ling LSC, et al. Systematic review of efficacy and safety of newer antidiabetic drugs approved from 2013 to 2017 in controlling HbA1c in diabetes patients. Pharmacy. 2018;6:57.

Montori VM, Basu A, Erwin PJ, Velosa JA, Gabriel SE, Kudva YC. Posttransplantation diabetes: A systematic review of the literature. Diabetes Care. 2002;25(3):583-92.

Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose co-transport (SGLT) inhibitors. Systematic review and meta-analysis of randomized trials. Ann Med. 2012;44(4):375-93.

Kavyashree AC, Mamatha K, Prabhu S, Kamath L. A comparative study to evaluate the efficacy of metformin monotherapy on glycemic markers in normal weight, and obese patients with Type 2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2022;12(1):49-54.

Raji A, Xu ZJ, Lam RLH, O’Neill EA, Kaufman KD, Engel SS. Efficacy and safety of sitagliptin compared with dapagliflozin in people 65 years old with type 2 diabetes and mild renal insufficiency. Diabetes Ther. 2020;11:2419-28.

Hussey EK, Kapur A, O’Connor-Semmes R, Tao W, Rafferty B, Polli JW, et al. Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when coadministered in subjects with type 2 diabetes mellitus. BMC Pharmacol Toxicol. 2013;14:25.

Frias JP, Zimmer Z, Lam RLH, Amorin G, Ntabadde C, Iredale C, et al. Double-blind, randomized clinical trial assessing the efficacy and safety of early initiation of sitagliptin during metformin uptitration in the treatment of patients with type 2 diabetes: The CompoSIT-M study. Diabetes Obes Metab. 2019;21:1128-35.

Paavilainen E, Tertti K, Nikkinen H, Veijola R, Vaarasmaki M, Loo B-M, et al. Metformin versus insulin therapy for gestational diabetes: Effects of offspring anthropometrics and metabolism at the age of 9 years: A follow-up study of two open-label, randomized controlled trials. Diabetes Obes Metab. 2022;24(3):402-10.

Ng C-AW, Jiang AA, Toh EMS, Ng CH, Ong ZH, Peng S, et al. Meformin and colorectal cancer: a systematic review, meta-analysis and meta-regression. Int J Colorectal Dis. 2022;35(8):1501-12.

Tarry-Adkins JL, Ozanne SE, Aiken CE. Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. Sci Rep. 2021;11(1):1-13.

Rahmani J, Manzari N, Thompson J, Gudi SK, Chhabra M, Naik G, et al. The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials. Clin Transl Oncol. 2020;22(1):37-49.

Yarandi RB, Behboudi-Gandevani S, Amiri M, Tehrani FR. Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression. Diabetol Metab Syndr. 2019;11(1):1-8.

Lord JM, Flight IHK, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327:951.




How to Cite

Hazra, M. (2022). A systematic review on metformin rational pharmacotherapeutics. International Journal of Basic & Clinical Pharmacology, 11(4), 331–335. https://doi.org/10.18203/2319-2003.ijbcp20221600



Systematic Reviews