Effect of honey and ginger mixture on productive cough in pediatrics patients
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20221038Keywords:
Productive cough, Honey, GingerAbstract
Background: Cough is common problem in pediatric age. Most of the parents use over the counter drugs along with cough syrups. Most of the cough syrup causes drowsiness and sedation as an adverse effect. So considering this we use ginger and honey mixture for treatment of productive cough to see its effectiveness. In Ayurveda, it is used since ancient time and in Indian it is used for home remedy for treatment of cough.
Methods: We selected patient attended pediatric outpatient department (OPD) complaining of productive cough. We selected 90 patients and divided in to three groups 30 patient in each group. Group I we gave antibiotics, antihistaminic with syrup ascoril (ambroxol 30 mg/5 ml and levosalbutamol 1 mg/5 ml and guaifenesin 50 mg/5 ml). Group II antibiotics, antihistaminic with honey and ginger mixture. In group III we gave antibiotic with antihistaminic along with both honey and ginger mixture with syrup ascoril. After this complete follow up to 10 days on mobile performed. We observed for occurrence of any deterioration of condition with occurrence adverse effect and how many days were required for improvement of patient condition.
Results: We got very promising results were we saw improvement in symptom in 6 day with honey and ginger group as compared to cough syrup group were p value is significant and highly significant (<0.005 and 0.001 respectively) with minimal acceptable adverse effect.
Conclusions: So from our study we can conclude the honey and ginger mixture is promising treatment of productive cough with less side effects.
References
Chung KF, Pavord ID. Prevalence, pathogenesis and causes of chronic coughs. Lancet. 2008;371(9621):1364-74.
Gibson PG, Ryan NM. Cough Pharmacotherapy. Current and Future Status. Expert Opin Pharmcather. 2011;12.
Sultana S, Khan A. Cough Suppressant Herbal Drugs: A Review. Int J Pharm Sci Intervent. 2016;5(5):15-28.
Arroll B. Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir Med. 2005;99:1477-84.
Finkle WD, Adams JL, Greenland S, Melmon KL. Increased risk of serious injury following an initial prescription for diphenhydramine. Ann Allergy Asthma Immunol. 2002;89:244-50.
Dart RC, Paul IM, Bond GR, Winston DC, Manoguerra AS, Palmer RB, et al. Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications. Ann Emerg Med. 2009;53:411-7.
Rimsza ME, Newberry S. Unexpected infant deaths associated with use of cough and cold medications. Pediatrics. 2008;122:318-22.
Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol. 2000;19:489-95.
Finkle WD, Adams JL, Greenland S, Melmon KL. Increased risk of serious injury following an initial prescription for diphenhydramine. Ann Allergy Asthma Immunol. 2002;89:244-50.
De Nesnera AP. Diphenhydramine dependence: A need for awareness. J Clin Psychiatry.1996;57:136-7.
Jones J, Dougherty J, Cannon L. Diphenhydramine-induced toxic psychosis. Am J Emerg Med. 1986;4:369-71.
The Siddha Pharmacopoeia of India (SPI), Part I, Vol I. Central Council for Research in Ayurveda and Siddha, New Delhi, India. 2008;69-71.
Sultana S, Khan A, Safhi MM, Alhazmi HA. Cough Suppressant Herbal Drugs: A Review. Int J Pharm Sci Invent. 2016;5(5):15-8.
Jaybhaye DL, Chandra S, Johar S, Nagre AS. Comparative effect of mixture of ginger and honey with dextromethorphan in dry cough in children. Int J Basic Clin Pharmacol. 2021;10:545-51.
Paul IM, Beiler J, McMonagle A. Effect of Honey, Dextromethorphan, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents. Arch Pediatr Adolesc Med. 2007;161(12):1140-6.
Sanz ML, Gonzalez M, De Lorenzo C, Sanz J, MatinezCastro I. Carbohydrate composition and physico chemical properties of artisanal honeys from Madrid (Spain): occurrence of Echium sp. honey. J Sci Food Agriculture. 2004;84(12):1577-84.
Hermosin I, Chicon RM, Cabezudo MD. Free amino acid composition and botanical origin of honey. Food Chem. 2003;83(2):263-8.
Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Therap. 2002;96(2-3):67-202.
Nagai T, Inoue R, Kanamori N, Suzuki N, Nagashima T. Characterization of honey from different floral sources. Its functional properties and effect of honey species on storage meat. Food Chem. 2006;97(2):256-62.
Zeina B, Othman O, al-Assad S. Effects of honey versus thyme on rubella virus survival in vitro. J Alternat Complement Med. 1996;2(3):345-8.
Adeleye IA, Opiah L. Antimicrobial activities of local cough mixtures on upper respiratory tract bacterial pathogens. West Indian Med J. 2003;52(3):188-90.
Raja W, Pandey S, Hanfi S, Khan A. Evaluation of antibacterial and anticough forming effects of Zingiber officinale extract. J Chem Pharm Res. 2012;11(6):1716-2319.
Snidvongs K, Seresirikachorn K, Khattiyawittayakun L, Chitsuthipakorn W. Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies. Drugs. 2017;77(2):175-86.