DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20163208

Comparison of efficacy and safety of thiocolchicoside and pregabalin in the treatment of acute non-specific low back pain: an open label randomized prospective study

Jui M. Shah, Kamlesh Patel, Manish R. Shah, Devang Rana, Supriya Malhotra

Abstract


Background: The present study was undertaken to study the efficacy and safety of thiocolchicoside, a centrally acting skeletal muscle relaxant, GABA mimetic drug and pregabalin, an anti-epileptic, GABA mimetic drug in the treatment of acute non-specific low back pain.

Methods: The study was carried out at the orthopaedic outpatient department of our hospital. 80 patients were included during the study period of two months. Out of the 80, 40 were given pregabalin 75 mg 1hs and the rest were given thiocolchicoside 8 mg bd by the prescribing doctor. Patients, aged between 18-60 years having non-radiating low back pain for less than 7 days were selected. The data was collected in a proforma which included the patient’s details and the prescribed drugs. The patients were also given notepads to record adverse effects. On day 1, the pain was measured on visual analogue scale. After a week, follow up was done and decrease in pain was measured on the visual analogue scale.

Results: There was significant difference between pre and post visual analogue scale score in both the groups with a p-value of less than 0.0001. But the difference between the two groups was not statistically significant (p-value 0.0664). In both the groups, patients did not report any adverse effects. Pregabalin has a slower onset than thiocolchicoside however has better efficacy. In India, where the drug abuse risk is higher, pregabalin is a safer choice as skeletal muscle relaxants (thiocolchicoside) should not be given for more than a week.

Conclusions: Pregabalin has better efficacy in treatment of acute non-specific low back pain as compared to thiocolchicoside.


Keywords


Acute non-specific low back pain, Comparative, Efficacy, Pregabalin, Thiocolchicoside

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References


Deyo RA, Weinstein J. Low back pain. N Engl J Med. 2001;344:363-71.

Waddell G. The Back Pain Revolution. Edinburgh. Churchill Livingstone. 1998.

KD Tripathi: Essentials of Medical Pharmacology, 7th edition; 358:420.

Freynhagen R, Grond S, Schupfer G, Hagebeuker A, Schmelz M, Ziegler D, et al. Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine. Int J Clin Pract. 2007;61(12):1989-96.

Soonawalla DF, Joshi N. Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. J Indian Med Assoc. 2008;106(5):331-5.

Lahoti G. To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. J Indian Med Assoc. 2012;110(1):56-8.

Sakai Y, Ito K. Comparison of pregabalin and opioids for chronic low back pain in elderly patients. Eur Spine J. 2015;24(6):1309-17.

Plapler PG, Scheinberg MA, Ecclissato CDC, Oliveira MFB, Amazonas RB. Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain. Drug Des Devel Ther. 2016;10:1987-93.

Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R. Noninvasive treatments for low back pain. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016:16-EHC004-EF.

Friedman BW, Andrew A, Davitt M, Holden L, Solorzano C, Esses D. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial. J Am Med Asso. 2015;314(15):1572-80.