DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20220024

Efficacy of current treatments against hepatitis C virus

Jose M. Zepeda, Alejandro Murrieta, Javier Contreras, Felix Osuna, Luis Antonio Villalobos Calderon, Miriam Pérez, María Holanda García Ramírez, Omar De J. Dorantes

Abstract


It is estimated that currently, in the world, approximately 3% of the population has chronic hepatitis, the hepatitis C virus is the etiological agent most related to the development of this pathology. The diversity of genotypes (7) and quasi-species of HCV, due to its high mutation rate, interferes with an effective humoral immunity. The aim of this work is precisely to evoke those usual drugs used in HCV therapy, as well as cutting-edge drugs. The goal of treatment is the eradication of HCV infection. One strategy offered by the WHO is to eradicate the virus in at-risk populations. Alternatives to the previously used treatment with interferon and ribavirin are shown in this paper; protease inhibitors and other targets have now been developed to make eradication of the virus more effective.


Keywords


Hepatitis C virus, Chronic hepatitis, Treatment and drugs

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