Role of myeloid growth factors in chemotherapy induced neutropenia

Authors

  • Ravinutala Srinath Bharadwaj Department of Radiation Oncology, MNJ Institute of Oncology and Regional Cancer Centre/Osmania Medical College, Hyderabad, India
  • Donepudi Aruna Department of Clinical Pharmacology and Therapeutics Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20163205

Keywords:

CIN, CSFs, Dose dense chemotherapy

Abstract

Neutropenia is a major dose limiting toxicity of many chemo therapeutic regimens. Haemopoietic colony - stimulating factors (CSFs) have been shown to reduce the duration and severity of chemotherapy induced neutropenia (CIN) and risk of febrile neutropenia. Supportive care with myeloid growth factors improve chemotherapy delivery by minimizing chemotherapy dose reductions or treatment delays by enabling the delivery of full dose chemotherapy (dose dense) in short time intervals. The goal of this article is to give comprehensive review of current literature regarding medical practice guidelines and risk assessment models for appropriate use of myeloid growth factors and management of febrile neutropenia.

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Published

2017-01-10

How to Cite

Bharadwaj, R. S., & Aruna, D. (2017). Role of myeloid growth factors in chemotherapy induced neutropenia. International Journal of Basic & Clinical Pharmacology, 5(5), 1715–1721. https://doi.org/10.18203/2319-2003.ijbcp20163205

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Section

Review Articles