Study of role of vitamin C in type 2 diabetes mellitus patients
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20214890Keywords:
Supplementation, Effective, Affordable, OADs, Vitamin CAbstract
Background: Diabetes mellitus (DM) is the most common non-communicable diseases in the present millennium which has become a global public health problem. The treatment of type 2 Diabetes mellitus (T2 DM) often is initiated with monotherapy of oral antidiabetic drugs (OADs), which often do not decrease the plasma sugar levels effectively and consistently that will reduce short term and long-term complications associated with T2 DM. Hence the current study is aimed to determine the effectiveness of vitamin C supplementation with standard OADs on glycemic control.
Methods: This study consisted of 120 T2 DM patients with 80 males and 40 females with a mean age of 50.88 yrs were divided into four groups with equal number of males and females in each group depending upon the OADs they received in solo or with vitamin C for 12 weeks. After the written consent, a detail clinical history, clinical examination, biochemical investigations including fasting plasma sugar (FPS), post prandial plasma sugar (PPS), glycosylated hemoglobin (HBA1c), serum creatinine, serum electrolytes, chest X-ray PA view and standard ECG were done. Repeat FPS, PPS and HBA1c were done after 4, 8 and 12 weeks of study.
Results: After 12 weeks of study FBS, PPS and HBA1c decreased significantly (p<0.01) in study groups (Metformin and teneligliptin with vitamin C) as compared to control groups (OADs without vitamin C). Vitamin C supplementation with OADs found to be effective, well tolerated and devoid of any side effects.
Conclusions: OADs are effective and affordable hypoglycemic agents with vitamin C supplementation.
References
IDF Diabetes Atlas, 7th Edn. Brussels, Belgium: International Diabetes Federation. 2015;3:55.
Kumar A, Nagtilak S, Sivakanesan R, Gunasekera S. Cardiovascular Risk Factors in Elderly Normolipidemic Acute Myocardial Infarct Patients-A Case Controlled Study from India. Southeast Asian J Trop Med Public Health. 2009;40(3):581-92.
Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol. 2009;157(7):1097-10.
Mann GV. Hypothesis: the role of vitamin C in diabetic angiopathy. Perspect Biol Med. 1974;17(2):210-7.
Ronchetti IP, Quaglino D Jr, Bergamini G. Ascorbic acid and connective tissue. Subcell Biochem. 1996;25:249-64.
Rumsey SC, Kwon O, Xu GW, Burant CF, Simpson I, Levine M. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997;272(30):18982-9.
Vera JC, Rivas CI, Fischbarg J, Golde DW. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature. 1993;364(6432):79-82.
Stankova L, Riddle M, Larned J. Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. Metabolism. 1984;33(4):347–353.
Mann GV, Newton P. The membrane transport of ascorbic acid. Ann N Y Acad Sci. 1975;258:243-52.
Will JC, Byers T. Does diabetes mellitus increase the requirement for vitamin C? Nutr Rev. 1996;54(7):193-202.
Opara EC. Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control. J Investig Med. 2004;52(1):19-23.
American Diabetic Association. Diagnosis and Classification of diabetes mellitus: Standards of Medical Care in Diabetes. Daibetes Care.2019;42(1):S13-28.
Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutri Metabolism. 1995;39(4):217-23.
Sargent LA, Wareham NJ, Bingham S, Day NE, Luben RN, Oakes S et al. Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care. 2000;23:726-32.
Sridulyakul P, Chakraphan D, Patumraj S. Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats. Clin Hemorheol Microcirculation. 2006;34(1-2):315-21.
Ardekani MA, Mohiti J, Amirchaghmaghi E, Modarresi M. The effect of vitamin C supplementation on insulin level, HBA1c and blood glucose in type 2 diabetic patients. J Kerman University Med Sci. 2006;11:12-8.
Dakhale GN, Chaudhari HV, Shrivastava M. Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind study. Adv Pharmacol Sci. 2011;2011:195-271.
Bhatt JK, Thomas S, Nanjan MJ. Effect of oral supplementation of vitamin C on glycemic control and lipid profile in patients with type 2 diabetes mellitus. Int J Pharm Pharm Sci. 2012;4:524-7.
Tabatabaei-Malazy O, Nikfar S, Larijani B, Abdollahi M. Influence of Ascorbic Acid Supplementation on Type 2 Diabetes Mellitus in Observational and Randomized Controlled Trials: A Systematic Review with Meta-Analysis. J Pharm Pharm Sci. 2014;17(4):554-82.
Ashor AW, Werner AD, Lara J, Wills ND, Mthers JC, Siervo M. Effects of vitamin C supplementation on glycaemic control:a systemic and meta-analysis of randomized controlled trials. E J Clin Nutri. 2017;71:1371-80.
Eriksson J, Kohvakka A, Kagan VE, Melhem M, Studer RK. Effects of supplementation with vitamin C or E on albuminuria, glomerular IGF-β and glomerular size in diabetics. J Amer Soci Nephrol. 1997;89(9):1405-14.
