A global analytical molecular pharmacological study of the endocrinological pharmacotherapeutic rationale of anti-diabetic prescriptions appraisal attributes for metformin and sitagliptin, with evaluation of anti-diabetic tertiary medical healthcare patient satisfaction

Moumita Hazra

doi:10.18203/2319-2003.ijbcp20214505

Authors

Moumita Hazra Department of Pharmacology, Mamata Medical College and Hospitals, Khammam, Telangana, India; Department of Pharmacology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India; Medical Director, Medical Superintendent, Laboratory Director, Medical Academics and Research Director, Consultant Clinical Pharmacological Physician, Consultant Clinical Pathologist, Consultant Drug Quality and Safety Physician, Pharmaco-Haemo-Materio-Vigilance Specialist, Dr. Moumita Hazra’s Polyclinic and Diagnostic Centre, Dr. Moumita Hazra’s Academic Centre, Dr. Moumita Hazra’s Educational Centre, Hazra Nursing Home, Howrah, Kolkata, West Bengal, India, World; Former Assistant Medical Director, GIOSTAR IRM Institutes, Hospitals and Laboratories, New Delhi, India, USA, World

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20214505

Keywords:

Biguanides, Dipeptidyl peptidase-4 inhibitors, Prescription’s appraisal, Patient compliance, Molecular Pharmacology, Anti-diabetic medical healthcare patient satisfaction

Abstract

Background: The inhibition of dipeptidyl peptidase-4 by anti-diabetic drugs dipeptidyl peptidase-4 inhibitors enhances hormonal activity of incretins (GLP-1, GIP, GRP), stimulates insulin release and reduces glucagon secretion, producing anti-hyperglycaemic activity among type II diabetics. The objective of this study was a global analytical molecular pharmacological study of the endocrinological rationale of anti-diabetic prescriptions appraisal attributes for metformin and sitagliptin, along with anti-diabetic tertiary medical healthcare patient satisfaction evaluation.

Methods: 100 new early moderate grade type II diabetics were prescribed oral metformin 500 mg or sitagliptin 25 mg once daily for 3 months, in monotherapy, or in combination therapy, or in a mixed regimen of monotherapy and combination therapy. The patients’ endocrinological pharmacotherapeutic compliance was analysed. The number of prescriptions for metformin and sitagliptin was recorded; and prescription percentages were calculated. The completeness and molecular basis of prescription content attributes were analysed. The molecular basis of anti-diabetic pharmacotherapeutics, was analysed. The anti-diabetic tertiary medical healthcare patient satisfaction was evaluated by patient response to different attributes of anti-diabetic treatment.

Results: All the patients had completed the study, with no adverse effects related drop-out, lost to follow-up or voluntarily withdrawn patients. The prescription rates of metformin was 75% (75 prescriptions), followed by sitagliptin: 25% (25 prescriptions).100% prescriptions were complete for each prescription content attribute. The molecular pharmacotherapeutic response mechanisms were significantly efficacious. All the patients were satisfied with each anti-diabetic medical healthcare attribute.

Conclusions: The patient endocrinological pharmacotherapeutic compliance was significantly high. Metformin was most commonly prescribed, followed by sitagliptin. The prescription content analyses showed 100% completeness, with significant pharmacotherapeutic molecular efficacy. There was ample anti-diabetic medical healthcare satisfaction.

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