Pharmacological investigations of neuroprotective potential of Centella lujica supplement on sleep deprivation-induced anxiety-like behaviour in mice

Authors

  • Anthony T. Eduviere Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria http://orcid.org/0000-0001-6822-7672
  • Prosper E. Awhin Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria
  • Kesiena E. Edje Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
  • Lily O. Otomewo Delta State University, Abraka
  • Emuesiri G. Moke Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
  • Adrian I. Omogbiya Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
  • Oghenemaro P. Idiowa Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20214113

Keywords:

Centella lujica, Locomotion, Anxiety, Sleep deprivation

Abstract

Background: Sleep deprivation has often been implicated in several neurological disorders. Centella lujica is a psychoactive herb with medically-beneficial therapeutic potential. The current study sought to evaluate the neuroprotective effect of Centella lujica supplement in experimental animals.

Methods: Sleep deprivation in mice was done using the multiple platforms over water model.

Results: Upon treatment with Centella lujica supplement, the parameters of anxiety-like behaviour induced by sleep deprivation were found to be significantly diminished in comparison to the sleep deprived animals.

Conclusions: Centella lujica treatment significantly decreased hyper locomotion, and anxiety-like behaviour caused by sleep deprivation.

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Author Biographies

Anthony T. Eduviere, Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

Department of Pharmacology and Therapeutics

Prosper E. Awhin, Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria

Department of Medical Biochemistry

Kesiena E. Edje, Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

Department of Pharmacology and Therapeutics

Lily O. Otomewo, Delta State University, Abraka

Department of Pharmacology and Therapeutics

Emuesiri G. Moke, Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

Department of Pharmacology and Therapeutics

Adrian I. Omogbiya, Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

Department of Pharmacology and Therapeutics

Oghenemaro P. Idiowa, Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria

Department of Pharmacology and Therapeutics

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Published

2021-10-22

How to Cite

Eduviere, A. T., Awhin, P. E., Edje, K. E., Otomewo, L. O., Moke, E. G., Omogbiya, A. I., & Idiowa, O. P. (2021). Pharmacological investigations of neuroprotective potential of Centella lujica supplement on sleep deprivation-induced anxiety-like behaviour in mice. International Journal of Basic & Clinical Pharmacology, 10(11), 1227–1233. https://doi.org/10.18203/2319-2003.ijbcp20214113

Issue

Vol. 10 No. 11 (2021): November 2021

Section

Original Research Articles
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