Risperidone induced pancytopenia: a case report

Authors

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20212932

Keywords:

Thrombocytopenia, Neutropenia, Leukopenia, Antipaychotic, Hematological side effect

Abstract

There are several case reports on hematological side effects after using antipsychotics in the literature. This case report could be the first case report of pancytopenia where laboratory work showed thrombocytopenia, lymphocytopenia, and neutropenia after using risperidone. It is about 14-year-old female presented with irritable mood and aggression started on Risperidone 0.75 mg every night. A few weeks later she developed frequent and recurrent urinary tract infections and heavy vaginal bleeding that lasted for 5 days and reoccurred twice in the same month. Patient was admitted to internal medicine ward to investigate the cause of bleeding. No signs of splenomegaly, hepatomegaly, or lymph node enlargement were observed. All immunological workup results were negative. Bone morrow showed normal cellularity with granulocytic hyperplasia, suggesting a peripheral cause that was most likely a drug-induced effect. A provisional diagnosis of drug-induced pancytopenia was established. These hematological side effects may make physician to be more careful while prescribing risperidone and to follow the guideline of regular lab work especially CBC.

Author Biography

Nader M. Alrahili, Department of Neuroscience, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

College of medicine - neuroscience department

 

Assiastant Profesor of psychiatry

 

References

Flanagan, Robert J, Dunk L. Haematological toxicity of drugs used in psychiatry. Human Psychopharmacology: Clinical and Experimental. 2008;23:S27-41.‏

Lieberman, Jeffrey A. Maximizing clozapine therapy: managing side effects. The Journal of clinical psychiatry. 1988;59(3):38-43.‏

Muhammad R. Bicytopenia: adverse effect of risperidone. Current Psychiatry. 2014;13(4):E1.‏

Hung, Yuan C, Bai YM. Risperidone-induced Leukopenia and Neutropenia. Taiwanese Journal of Psychiatry (Taipei). 1988;25(2):119.‏

Jerome G. Approach to pancytopenia: Diagnostic algorithm for clinical hematologists. Blood reviews. 2018;32(5):361-7.‏

Chiravuri S, De Jesus O. Pancytopenia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK563146/. Accessed on

Badii A, Chebbi W, Mhalla A, Soumaya F, Nadia F, Karim A et al. Risperidone-induced thrombocytopenia. 2017;(6):926-30.

Dipanjan B. Risperidone induced isolated thrombocytopenia: a rare adverse event. Psychopharmacology bulletin. 2018;48(3):47.‏

Jun'ichi S, Okui S. Risperidone-induced thrombocytopenia: a case report. General hospital psychiatry. 2009;31(1):97-8.‏

Kailasam, Kattalai V. Risperidone-induced reversible neutropenia. Neuropsychiatric disease and treatment. 2017;13:1975.‏

Downloads

Published

2021-07-26

How to Cite

Alrahili, N. M. (2021). Risperidone induced pancytopenia: a case report. International Journal of Basic & Clinical Pharmacology, 10(8), 1016–1018. https://doi.org/10.18203/2319-2003.ijbcp20212932

Issue

Section

Case Reports