Evaluation of effect of Calotropis gigantea root bark in some animal models of Wister albino rats
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20212375Keywords:
Antiasthmatic, Bronchoconstriction, Calotropis gigantea, Anti-inflammatoryAbstract
Background: Calotropis gigantea is a well-documented traditional medicinal plant useful for many disease conditions. The present study deals with the effect of alcoholic extract of roots bark of Calotropis gigantean in some animal models.
Methods: Acute anti-inflammatory activity of root extract was assessed on carrageenin induced paw edema and chronic antiinflammatory activity on cotton pellet granuloma formation in rats and compared with standard diclofenac sodium. Antiasthmatic activity was assessed in histamine and actylcholine induced bronchoconstriction in guinea pigs.
Results: 100 and 200 mg/kg p.o. root extract of CG showed significant anti-inflammatory and bronchodilator activity. Antiinflammatory activity was higher than Diclofenac Sodium 50mg/kg. The combination of low dose diclofenac sodium 25mg/kg potentiated the effect. Inhibitory effect on synthesis and release of various inflammatory mediators might contribute to both of these actions. Steroid like phytoconstituents might be responsible for these effects. Further research is needed to understand the exact mechanism behind these effects.
Conclusions: In the present study Calotropis gigantea root bark exhibited anti-inflammatory activity in animal models.
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Gupta J, Mohammad A. Rare chemical constituents from calotropis gigantean roots. Indian J Pharm Sci. 2000;629(1):29-32.
Sheth UK, Dadkar NK, Kamath UG. Selected topics in experimental pharmacology. Mumbai: Kothari book depot; 1972:5;63.
Rao KS, MIshra SH. Studies on Calotropis gigantia for anti-inflammatory and hepatoprotective activities. Indian Drugs. 2004;33:20-50.
Upadhyay RK. Ethnomedicinal, pharmaceutical and pesticidal uses of calotropis procera. Int J Green Pharm. 2014;8:135-46.
Jacinto Sd, Chun EAC, Montuno AS, Shen CC, Espineli D, Ragasa CY. Cytotoxic cardenolide and sterols from calotropis gigantia. Natural Product Comm. 2011;6(6):803-6.
Hani S, Al Mezaine, Ali A, Al Razi, Al Assiri a,Mihael D, Wagoner. Caloptropis keratitis. American J Ophthalmol. 2005:139(1):199-202.
Pathak AK. Analgesic anti-inflammatory activity of calotropis gigantea flower. J Ethnopharmacol. 2007; 78(1):40-4.
Khadar S. calotropis gigantean (Apocynaceae): A phytochemical and pharmacological review. J Ethnolpharmacol. 2013;150(1):32-50.
Rahulmayee, Thosar A, Kondapure A. Evaluation of antiasthmatic activity of calotrois gigantia roots. Asian J Pharm Res. 2011;4(2):11.
Rasik AM, Raghubir R, Gupta A. Healing potential of calotropis procera on dermal wounds in guinea pigs. J Ethnolpharmacol. 1999;68(1-3):261-6.
Jiji Mol VC, Shanmuga P, Madhavan R, Murugesan S, Manjari V, Murugasan M. A siddha polyherbal formulation for bronchial asthma: A Review. Ind Asian J Pharma Sci. 2015;2(2):592-95.
Parthiban P, Samraj K, Kanakavalli K. A review on antiasthmatic herbs in siddha medicine. Ind J Pharma Sci Res. 2014;26(1):25.
Adak M, Gupta JK. Evaluation of anti-inflammatory activity of calotropis gigantean invarious biological system. NMCI. 2006;8(3):156-61.
Emilie A, Francois C, Genevieve B, et al. Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review. J Ethnopharmacol. 2019;234:119-53.
Gupta KD, Bharti D. Studyof aniinflammatory activity of calotropis gigamtea and calotropis provera in flower extract. Ind J of Med Res. 2013;120:9-11.
Deshmukh PT, Akar JF. Wound healing activity of calotropis gigantea root bark in rats. J Ethnopharmacol. 2009;125(1):178-81.
Basu A, Chaudhuri AKN. Preliminary studies on the anti-inflammatory and analgesic activities of calotropis procera root extract. J Ethnopharmacol. 1991;31(3):319-24.
Savla A, Deshmukh P. Calotropis gigentea root bark extract accelerates wound healing in rats. J Ethnopharmacol. 2010;125(1):178.
Chandrasekar R, chandrasekar S. Natural herbal treatment for rheumatoid arthritis: A review. Int J Pharma Sci Res. J Ethnopharmacol. 2010;125(3):17.
Parmar N, Rawat M, Kumar T. Evaluation of potential of kigelia pinnata in wistar rats. Asian J Pharma Clin Res. 2012;5(10):95-7.
Awasthi S, Irshad MD, Das M, Ganti SS, Moshahid A, Razvi A. Antiinflammatory activity of calotropis gigantia and tridax procumbens on carrageenin induced paw edema in rats. Ethnobotanical Leaflets. 2009;13:568-77.
Karbab A, Mubarak MS. Study of anti-inflammatory activity of calotropis gigantia flower extract. J Ethnopharmacol. 2020;258(1):112.
Gupta PK. Illustrated Toxicology. USA: Elsevier; 2018.
Auditeau E, Chassagne F. Herbal medicine for epilepsy seizures in Asia, Africa and Latin America. J Ethnopharmacol. 2019;234:119.
Cardinolides: Insights from chemical structure and pharmacological utility. Pharma Res. 2019;141:123-175.
Kadiyala M, Ponnusankar S, Elango K. Calotropis gigantean (Apocynaceae): A phytochemical and pharmacological review. J Ethnopharmacol. 2013; 150:32-50.
Kadiyala M, Elango K. Aak plant (calotropis gigantea) benefits: nature gift for diabetes, obesity and arthritis). J Ethnopharmacol. 2013;150:15.
Chauhan MA. Madar (calotropis gigantea): Uses, benefits, dosage and properties. Res Ayur Sci. 2019; 203:777.
Salem W, Sayed W, Haridy M. Antibacterial activity of calotropis procera on pathogenic organisms. African J Biotech. 2014;13(32):3271-80.
Nalwaya N, Pokharna g, Lokeshdeb B, Jain N. Wound healing activity of latex of calotropis gigantean. Int J Pharma Sci. 2009;1(1):12.
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