DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20162425

Dissimilarity of absorbing internal radiation dose of 99mTc- diethylenetriaminepentacetate among male, female and international committee for radiation protection - 53 recommended data

Md. Nazrul Islam, Debendra Nath Roy

Abstract


Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiolabelling. The two most common radiolabelled pharmaceutical agents used are Tc99m-MAG3 (MAG3 is also called mercaptoacetyltriglycine) and Tc-99m-DTPA (diethylenetriaminepentacetate). Tc-99m-DTPA is filtered by the glomerulus and used to measure the glomerular filtration rate and is the second most commonly used renal radiopharmaceutical, primarily because it is the least expensive. The main objective of the present study was to obtain the bio-kinetic data of organ activity as well as organ absorbed dose of Tc99m-DTPA for single photon emitters.

Methods: We have carried out a method to obtain accurate organ activity with single photon emission computed tomography (SPECT). Tc-99m-DTPA radiopharmaceutical medicine was used as single photon emitters and we have demonstrated effective decay method and conventional method to obtain accurate organ (seven) activity with single photon emission computed SPECT. The observed organ activity is due to the Tc99m-DTPA is obtained and the data is compared among male, female and ICRP (international committee for radiation protection)-53 recommended data as well.

Results: The outcome of study revealed that, dose absorbed power of male is greater than female, so in nuclear medicine centre absorbed doses should be estimated separately both for male and female for more proper treatment opportunity. It is also observed that there is no good agreement of absorbed dose values among male, female and ICRP-53 recommended data.

Conclusions: Our achieved result is due to the extreme variation in food values and fundamental needed elements are certainly different between Bangladeshi peoples and foreigners. In case of foreigner’s it is almost equal for male and female, whereas for Bangladeshi male and female it is certainly different.


Keywords


Radiopharmaceuticals, Nuclear medicine, Organ activity, Dose

Full Text:

PDF

References


Marinelli LD. Dosage determinations with radioactive isotopes. I Nucleonics. 19484(1):56. II Nucleonics. 1948;(2)5:44.

Marinelli LD, Quimby EH, Hine GJ. Dosage determinations with radioactive isotopes II. Practical consideration in therapy and protection. Am J Roentgenol Radium Ther. 1948;59:260.

Mayneord WV. The mathematical theory of integral dose in radium therapy. Br J Radiol. 1945;18:260.

Loevinger R, Holt JG, Hine GJ, Brownell GL. Internally administered radioisotopes and radiation dosimetry. Academic press, New York; 1956.

Ellett WH, Callaman AB, Brownell GL. Gamma ray dosimetry of internal emitters. I Montecarlo calculations of absorbed dose from point source. Br J Radiol. 1964;37:45.

Ellett WH, Callaman AB, Brownell GL. Gamma ray dosimetry of internal emitters. I Montecarlo calculations of absorbed dose from uniform source. Br J Radiol. 1965;38:541.

Mird dose estimation report No. 8 Summary of current radiation dose. Estimates to normal human from 99mTc as sodium pertechnetate, JNM. 1976;17:74-7.

Loevinger R, Berman M. A schema for absorbed dose calculations for biologically-distributed redionuclides. Medical Internal Dose Committee (MIRD) pamphlet No. 1. J Nucl Med. 1968;9:Supp l1:7-14.

National Council on radiation Protection and measurements, NCRP report No. 83. The experimental basis for absorbed-dose calculations in medical uses of radionuclides. National council on Radiation Protection and Measurements. 7910 Woodmont Avenue, MD. 20814; 1985;6-56.

Brownel GL, Ackerman RH, Strauss WH. Preliminary imaging results with 18F-2-fluoro-2-deoxy-D-glucose. J comput Assit Tomogr. 1980;4:473-7.

Jones SC, Alvi A, Christman D, Montaned I, Wolf AP, Reivich M. The radiation dosimetry of 2-[18F] fluoro-2-deoxy-D-glucose in man. J Nucl Med. 1982;23:613-7.

Harvey J, Firnau G, Garrnett ES. Estimation of the radiation dose in human due to 6-[18F] fluoro-L-dopa. J Nucl Med. 1985;26:931-5.

Thonoor CM, Couch MW, Greer DM, Thomas KD, Williams CM. Biodistribution and radiation dosimetry of radioiodinated-SCH 23982, a potential dopamine D1 receptor imaging agent. J Nucl Med. 1988;29:1668-74.

Mark CW, James EC, Phillip SS, Micheal RK. Simplifying the dosimetry of carbon-11-labeled radiopharmaceuticals. J Nucl Med. 1997;38:654-60.

Bigler RE, Sgouros G. Biological analysis and dosimetry for 15O-labeled 15O2, C15O3 and C15O gases administered continuously by inhalation. J Nucl Med. 1983;24:431-7.

Subramanaya R, Alpert NM, Hoop BJ, Brownell GL, Tavera JM. A model for regional cerebral oxygen distribution during continuous inhalation of 15O2, C15O2 and C15O. J Nucl Med. 1978:19:48.

Charkes ND, Makler PT, Pilips C. Studies of skeletal tracer kinetics. 1 Digital-computer solution of a five-compartment model of [18F] fluoride kinetics in humans. J Nucl Med. 1978;19:1301-9.

Brihaye C, Depresseux JC, Comer D. Radiation dosimetry for bolus administration of oxygen-15-water. J Nucl Med. 1995;36:651-6.

Jones SC, Alvi A, Christman D, Montanex I, Wolf AP, Reivich M. The radiation dosimetry of 2-[18F] fluoro-2deoxy-D-glucose in man. J Nucl Med. 1982;23:613-7.

Mejia AA, Nakamura T, Itoh M, Hatazawa J, Masaki M, Watanuki S. Estimation of absorbed doses in human due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies. J Nucl Med. 1991;32:699-709.

Herzog H, Coenen HH, Kuwert T, Langen J. Feinendegen LE. Quantification of the whole-body distribution of PET radiopharmaceuticals, applied to 3-N-([18F] fluoroethyl) spiperone. Eur J Nucl Med. 1990;16:77-83.

Kearfott KJ. Radiation absorbed dose estimates for position emission tomography (PET): C15O. J Nucl Med. 1982;23:1031-7.

Deloar HM, Shidahara M, Fujiwara T, Watabe H, Narita Y, Itoh M, et al. Radiation absorbed dose estimates for 2-[F-18] Fluoro-2-Deoxy-D-Glucose by using whole body PET and MRI. J Nucl Med. 1998:25(6):565;74.

Meyer E, Yamamoto LY, Evans AC, Tyler JL, Dicsic M, Feindel W. Radiation dose to upper airways from inhaled oxygen-15 carbondioxide. J Nucl Med. 1987;28:234-9.

Huhi DE, Koeppe RA, Fesler JA, Minoshima S, Ackermann RJ, Carey JE, et al. In vivo mapping of cholinergic neurons in the human brain using SPET and IBVM. J Nucl Med. 1994;35:405-10.

Schmidt D, Langen KJ, Herzog H, Wirths J, Holschbach M, Kiwit JCW, et al. Whole-body Kinetics and dosimetry of L-3-[123I]iodo-α-methltyrosine. Eur J Nucl Med. 1997; 24:1162-6.

Dey HM, Seibyl JP, Stubbns JB, Zoghbi SS, Baldwin RM, Smith EO, et al. Human biodistrihution and dosimetry of the SOECT benzodiazepine receptor radioligand iodine-123-iomazenil. J Nucl Med. 1994;35:399-404.

Deloar HM, Fujiwara T, Shidahara M, Nakamura T, Yamadera A, Itoh M. Development of methodology to estimate internal radiation absorbed dose in nuclear medicine. Phys Med Biol. 1999;44(2):595-606.

Deloar HM, Nakamura T, Itih M, Fujwara T. Estimation of internal absorbed dose of L-[methyl-11C] nethioine using whole body PET. EUR JNM. 1998;25:629-33.

Deloar HM, Fujiwara T, Shidahar M, Nakamura T, Yamadera A, Itoh M. Internal absorbed dose estimation by a TDL method for 18F-FDG and comparison with the dose estimates from whole body PET. Eur JNM. 1998;25:565-74.

Alam M. Internal radiation absorbed dose estimation of technetium-99m radiopharmaceuticals in nuclear medicine (M. Sc. Thesis) Department of Physics, University of Rajshahi. 1999;20:593-601.

Loevinger R, Buidinger TF, Watson EE. MIRD primer for absorbed dose calculations. In collaboration with the MIRD committee. The Society of Nuclear Medicine, Inc. New York. 1991;21:79-89.

Mejia A. Internal dosimetry of positron emitting labeled radiopharmaceutical in nuclear medicine. Ph. D. Thesis, Department of Nuclear Engineering, Tohoku University, Japan; 1991;32:875-7.