Dissimilarity of absorbing internal radiation dose of 99mTc- diethylenetriaminepentacetate among male, female and international committee for radiation protection - 53 recommended data

Md. Nazrul Islam, Debendra Nath Roy


Background: Radioisotope tomography is a form of medical imaging of the kidneys that uses radiolabelling. The two most common radiolabelled pharmaceutical agents used are Tc99m-MAG3 (MAG3 is also called mercaptoacetyltriglycine) and Tc-99m-DTPA (diethylenetriaminepentacetate). Tc-99m-DTPA is filtered by the glomerulus and used to measure the glomerular filtration rate and is the second most commonly used renal radiopharmaceutical, primarily because it is the least expensive. The main objective of the present study was to obtain the bio-kinetic data of organ activity as well as organ absorbed dose of Tc99m-DTPA for single photon emitters.

Methods: We have carried out a method to obtain accurate organ activity with single photon emission computed tomography (SPECT). Tc-99m-DTPA radiopharmaceutical medicine was used as single photon emitters and we have demonstrated effective decay method and conventional method to obtain accurate organ (seven) activity with single photon emission computed SPECT. The observed organ activity is due to the Tc99m-DTPA is obtained and the data is compared among male, female and ICRP (international committee for radiation protection)-53 recommended data as well.

Results: The outcome of study revealed that, dose absorbed power of male is greater than female, so in nuclear medicine centre absorbed doses should be estimated separately both for male and female for more proper treatment opportunity. It is also observed that there is no good agreement of absorbed dose values among male, female and ICRP-53 recommended data.

Conclusions: Our achieved result is due to the extreme variation in food values and fundamental needed elements are certainly different between Bangladeshi peoples and foreigners. In case of foreigner’s it is almost equal for male and female, whereas for Bangladeshi male and female it is certainly different.


Radiopharmaceuticals, Nuclear medicine, Organ activity, Dose

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