Study of anti-inflammatory activity of omeprazole in complete Freund’s adjuvant induced arthritic rats

Authors

  • Nadia Nausheen Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India
  • Prabhakar Patil Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India
  • Yatish Byndoor Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164118

Keywords:

CFA, NSAIDS, PPI, RA

Abstract

Background: Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory disease, characterized by synovial proliferation and joint erosions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as an important part of therapeutic regime to suppress the pain and inflammation associated with RA. The modern drugs both steroidal and nonsteroidal anti-inflammatory drugs (NSAIDS) and disease modifying antirheumatic drugs (DMARDSs) are used for the amelioration of the symptoms of the disease; however, they offer only temporary relief and also produce adverse effects. This study was done to evaluate anti-inflammatory activity of Omeprazole in CFA induced arthritic rats.

Methods: Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Anti-inflammatory effect of group II Diclofenac sodium (10 mg/kg orally) and group III, IV and V received Omeprazole (10mg/kg, 20mg/kg, and 30mg/kg bodyweight orally respectively) was evaluated in adult albino rats by Plethysmometer on 7th, 14th and 21st day post adjuvant injection.

Results: Group 3 produced a significant suppression of paw volume with P value (<0.05) and Group 4 produced a very significant suppression with P value (<0.001) compared to other groups.

Conclusions: Omeprazole, a PPI, has anti-inflammatory activity.

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Published

2016-12-21

How to Cite

Nausheen, N., Patil, P., & Byndoor, Y. (2016). Study of anti-inflammatory activity of omeprazole in complete Freund’s adjuvant induced arthritic rats. International Journal of Basic & Clinical Pharmacology, 5(6), 2534–2537. https://doi.org/10.18203/2319-2003.ijbcp20164118

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Original Research Articles