Study of anti-inflammatory activity of omeprazole in complete Freund’s adjuvant induced arthritic rats

Nadia Nausheen; Prabhakar Patil; Yatish Byndoor

doi:10.18203/2319-2003.ijbcp20164118

Authors

Nadia Nausheen Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India
Prabhakar Patil Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India
Yatish Byndoor Department of Pharmacology, Navodaya medical college, Raichur, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164118

Keywords:

CFA, NSAIDS, PPI, RA

Abstract

Background: Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory disease, characterized by synovial proliferation and joint erosions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as an important part of therapeutic regime to suppress the pain and inflammation associated with RA. The modern drugs both steroidal and nonsteroidal anti-inflammatory drugs (NSAIDS) and disease modifying antirheumatic drugs (DMARDSs) are used for the amelioration of the symptoms of the disease; however, they offer only temporary relief and also produce adverse effects. This study was done to evaluate anti-inflammatory activity of Omeprazole in CFA induced arthritic rats.

Methods: Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Anti-inflammatory effect of group II Diclofenac sodium (10 mg/kg orally) and group III, IV and V received Omeprazole (10mg/kg, 20mg/kg, and 30mg/kg bodyweight orally respectively) was evaluated in adult albino rats by Plethysmometer on 7th, 14th and 21st day post adjuvant injection.

Results: Group 3 produced a significant suppression of paw volume with P value (<0.05) and Group 4 produced a very significant suppression with P value (<0.001) compared to other groups.

Conclusions: Omeprazole, a PPI, has anti-inflammatory activity.

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