Prescribing patterns of antihypertensive drugs in tertiary care teaching hospital
Keywords:Prescribing patterns, Diuretics, Hypertension
Background: Prescribing patterns provides prescribing behaviors of prescriber. Hypertension is most common cardiac complication among middle and old age population. Thus, study about prescribing trends helps to select appropriate drug for treatment of hypertension. The study aim was to analyze the patterns of antihypertensive drug prescribed in patients diagnosed with hypertension.
Methods: The study was cross sectional and observational study. A questionnaire was specifically designed factoring patients’ demographical profile, diagnosis of disease, drug regimen.
Results: The totals of 100 patients were analyzed for the prescribing patterns of antihypertensive drug maximum patients belonged to the age group of 61-80. The proportion of male (62%) patients was more as compared to female patients (38%). Total drug prescribed was 246 in 100 prescriptions. Average drug per prescription was 2.46. Among 246 drugs, 97% were antihypertensive prescribed and 3% were other concomitant drugs. 65% single drug prescribed, 25% two drug prescribed and 10% three drug prescribed. Most commonly single antihypertensive drug prescribed was telmisartan. Most commonly two antihypertensive drug prescribed was telmisartan + hydrochlorothiazide. Most commonly three antihypertensive drug prescribed was telmisartan + amlodipine + hydrochlorothiazide. Among total 246 drug prescribed, angiotensin receptor blocker was prescribed (ARB) 28%, calcium channel blocker (CCB) 17%, angiotensin converting enzyme inhibitor (ACEI) 12%, beta blocker 5% followed by ARB + diuretics 13%, ACEI + diuretics 8%, beta blocker + CCB 4%, ARB + CCB + diuretics 7%, ARB + beta blocker + diuretics 3% and 3% other drug prescribed. There was no fixed dose combination prescribed and no injectable prescribed in present study.
Conclusions: The most common drug prescribed was ARB as single drug therapy. The most common drug which was used for combination therapy was diuretics.
Rachana PR, Anuradha HV, MC Shivamurthy. Antihypertensive Prescribing Patterns and Cost Analysis for Primary Hypertension: A Retrospective Study. J Clinic Diagnost Res. 2014;8(9):19-22.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair- Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013;380:2224-60.
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.
Etuk E, Isezuo SA, Chika A, Akuche J, Ali M. Prescription pattern of antihypertensive drugs in a tertiary health institution in Nigeria. Ann Afric Med. 2008;7(3):128-32
Dighore PN, Patil PH, Kuchake VG, Maheshwari OD. Prescription patterns of antihypertensive drugs. Ind J Hospital Pharm. 2009;46:78-82.
Sikidar P, Chakravarty P, Purkayasyha A, Tigga R. A study on prescribing pattern of antihypertensives in adult patients attending in a tertiary care hospital of Assam, India. Int J Basic Clin Pharmacol. 2016;5:975-8.
Gupta R, Malhotra A, Malhotra P. Study of prescribing pattern of drugs used in the treatment of hypertension in a tertiary care teaching hospital in North India: an observational study. Int J Res Med Sci 2018;6:2380-4.
Bhavika D, Prasanna V, Swathi B. Drug utilization study of anti-hypertensive drugs in a tertiary care hospital. Int J Basic Clin Pharmacol 2016;5:1580-5.
Kaur S, Gupta S, Kumar D, Lal M, Gilani Z. Prescribing pattern of antihypertensive drugs in a tertiary care hospital in Jammu-A Descriptive study. JK-Practit. 2012;17(4):38-41.
Giri rajasekhar D, Guru prasanna D, Chandrakanth P. Prescribing pattern of antihypertensive drugs based on compelling indications with hypertension. Int J Pharm Pharm Sci 2019;8(2):72-5.