Angiotensin receptor/neprilysin inhibitor: a novel therapy in the treatment of heart failure

Rohini Gupta; Pavan Malhotra; Diwanshu Sharma

doi:10.18203/2319-2003.ijbcp20162423

Authors

Rohini Gupta Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India
Pavan Malhotra Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India
Diwanshu Sharma Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162423

Keywords:

Neprilysin, Sacubitril/valsartan, Heart failure, ARNI

Abstract

Recently US Food and Drug Administration (FDA) approved valsartan/sacubitril is the first angiotensin receptor/neprilysin inhibitor (ARNI) that offers a new standard of treatment to physicians for the patients of heart failure with reduced ejection fraction. Sacubitril is a prodrug which gets activated to sacubitrilat and this inhibits the enzyme neprilysin which is a membrane bound endopeptidase and which in turn is responsible for the degradation of various natriuretic peptides. The action of Valsartan which selectively blocks the angiotensin II type-1 receptor is needed in addition to sacubitril because inhibition of neprilysin is accompanied by the activation of renin-angiotensin system. The combination appears to be a suitable alternative for patients of heart failure with persistent symptoms or with recent exacerbation or hospitalization while on standard optimized treatment. The availability of this novel sacubitril/valsartan combination is an important development in the heart failure management.

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