Angiotensin receptor/neprilysin inhibitor: a novel therapy in the treatment of heart failure

Authors

  • Rohini Gupta Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India
  • Pavan Malhotra Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India
  • Diwanshu Sharma Department of Pharmacology and Therapeutics, SC College of Medical Sciences and Hospital, Sidhra, Jammu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162423

Keywords:

Neprilysin, Sacubitril/valsartan, Heart failure, ARNI

Abstract

Recently US Food and Drug Administration (FDA) approved valsartan/sacubitril is the first angiotensin receptor/neprilysin inhibitor (ARNI) that offers a new standard of treatment to physicians for the patients of heart failure with reduced ejection fraction. Sacubitril is a prodrug which gets activated to sacubitrilat and this inhibits the enzyme neprilysin which is a membrane bound endopeptidase and which in turn is responsible for the degradation of various natriuretic peptides. The action of Valsartan which selectively blocks the angiotensin II type-1 receptor is needed in addition to sacubitril because inhibition of neprilysin is accompanied by the activation of renin-angiotensin system. The combination appears to be a suitable alternative for patients of heart failure with persistent symptoms or with recent exacerbation or hospitalization while on standard optimized treatment. The availability of this novel sacubitril/valsartan combination is an important development in the heart failure management.

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Published

2017-01-05

How to Cite

Gupta, R., Malhotra, P., & Sharma, D. (2017). Angiotensin receptor/neprilysin inhibitor: a novel therapy in the treatment of heart failure. International Journal of Basic & Clinical Pharmacology, 5(4), 1175–1178. https://doi.org/10.18203/2319-2003.ijbcp20162423

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Review Articles