Efficacy of lysine versus mupirocin in the treatment of non-diabetic foot ulcer: the sessing scale for assessment of pressure ulcer

Sridhar Prasad Y. P.; Sandeep B.; Shashi Kumara; Prathima C.; Vani J.

doi:10.18203/2319-2003.ijbcp20205449

Authors

Sridhar Prasad Y. P. Department of Pharmacology, Chamarajanagar Institute of Medical sciences, Chamarajanagar, Karnataka
Sandeep B. Department of Pharmacology, Chamarajanagar Institute of Medical sciences, Chamarajanagar, Karnataka
Shashi Kumara Department of Pharmacology, Chamarajanagar Institute of Medical sciences, Chamarajanagar, Karnataka
Prathima C. Department of Pharmacology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka
Vani J. Department of Pharmacology, Akash Institute of Medical Sciences and Research, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20205449

Keywords:

Sessing scale, Non-diabetic foot ulcer, Lysine, Mupirocin

Abstract

Background: This present studies intended to evaluate the wound healing ability, efficacy and tolerability of lysine cream (15%) in non- diabetic foot ulcer assessed by way of sessing scale.

Methods: A randomized, open-label, interventional study was directed on 20 subjects (participants) non-diabetic ulcers. Participants were grouped into two groups, control (n=10) and case (n=10). The control was treated with standard treatment with mupirocin and the test group was treated with standard treatment alongside lysine cream (15%) twice every day. Wound healing in the participants was assessed by the sessing scales.

Results: A total of 20 participants were allotted into two groups. The results expressed as mean±standard deviation values imply the size and depth of the foot ulcer from the first week to the 8th week. Both the groups showed a significant increase the ulcer healing and decrease the pressure of foot ulcer of over a period of 8 weeks. Assessment of the first week showed no significant ulcer healing and its pressure. The overall outcome indicated that the lysine-treated group extensively reduced each of the parameters favouring wound healing than the standard therapy with mupirocin (control group).

Conclusions: Results concluded that, lysine cream is better efficacious in the repair of wound and additionally well tolerated compared to mupirocin.

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