Antifertility effect of curcumin, an indigenous medicine in rats
Keywords:Curcuma longa linn, Antifertility effect, Indigenous medicine
Background: Curcumin is an active constituent, obtained from rhizome of Curcuma longa linn, known to have broad medicinal properties, was studied for its effect on fertility in female rats. Curcumin has anti-ovulatory effect probably by its antiestrogenic activity through suppression of negative feedback of estrogen on pituitary.
Methods: Inbred Charles Foster female albino rats (150-180 gm) were used for study. They were divided into different groups and treated with curcumin (25 mg/kg. and 50 mg/kg body weight) as per schedule. The antigonadotropic, antiestrogenic, anti-implantation and abortifacient effect on curcumin treated albino rats were demonstrated.
Results: The results showed significant reduction in the number of implants and size of litters in curcumin treated rats compared to normal control group. The results were compared with Tamoxifen (10mg/ kg bodyweight) a known antifertility drug, which further substantiated the antifertility effects of curcumin.
Conclusions: The results indicated the ways in which curcumin exerts antifertility effects and thus can play a vital role in fertility control.
Ghosh AK, Das AK, Patra KK. Studies on antifertility effect of rhizome of Curcuma longa linn. Asian J Pharm Life Sci. 2011;1(4):349-53.
Kirtikar KR, Basu BD. Indian medical plants. Allahabad: Lalit Mohan publication; 1935.
Eigner D, Schlolz D. Ferula asa-foetida and Curcuma longa in traditional medicinal treatment and diet in Nepal. J Ethnopharmacol. 1999;67:1-6.
Dasgupta SR, Sinha M, Sahana CC, Mukherjee BP. A study of the effect of an extract of Curcuma longa Linn on experimental gastric ulcers in animals. Indian J Pharmacol. 1969;1(3):49-54.
Garg SK, Garg GP. Antifertility screening of plants, effect on pregnancy in albine rats. Indian J Med Res. 1971;59:302-6.
Fox BW, Jackson H, Laurence DR, Bacharalh AC. Evaluation of drug activities. London: Academic Press; 1964:2;801.
Garg SK, Mathur VS, Chaudhury RR. Screening of Indian plants for antifertility activity. Indian J Exp Biol. 1978;16(10):1077-9.
Laurence KA. Clinical chemistry, theory analysis and correlation. United States of America: CN Mosby Company; 1984:1145.
Garg SK, Mathur VS, Chaudhury RR. Screening of Indian plants for antifertility activity. Planta Med. 1978;26(3):225-7.
Atal CK. Chemistry and pharmacology of vasicine, a new oxytocic and abortifacient.Jammu Tawi: Regional Research Laboratory publishers; 1970:68-79.
Jordan VC, Dix C. Effect of oestradiol benzoate, tamoxifen andmonohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division. J Steriod Biochem. 1979;11:285-91.