Acute psychosis induced by topiramate

Rajnish Raj, Raj Kumar

Abstract


Topiramate (TPM) is a new potent antiepileptic drug (AED) used as add-on therapy for generalized and partial seizures that are resistant to the other AEDs; or as a mood stabilizer, and for reducing weight gain associated with olanzapine and clozapine in patients with bipolar disorder or schizophrenia. However, there is a higher risk of psychosis with TPM in patients with a past history of psychiatric disorder. This case report highlights emergence of psychosis that was related to TPM which resolved on discontinuation.


Keywords


Topiramate, Mania Rating Scale, Brief Psychiatric Rating Scale, Drug–drug interaction, CYP450

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References


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