Screening of anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats

Biacin Babu; Madhavrao Chavan

doi:10.18203/2319-2003.ijbcp20205023

Authors

Biacin Babu Department of Pharmacology, Malabar Medical College Hospital and Research Centre, Calicut, Kerala
Madhavrao Chavan Department of Pharmacology, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20205023

Keywords:

Albino rats, Carvedilol, Convulsions, Diphenylhydantoin, Epilepsy, Maximal electroshock seizure

Abstract

Background: Epilepsy is one of the major central nervous system disorders. The parent study aimed to screen the anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats.

Methods: This study was done in Wistar albino rats. A total of 30 rats were divided into 6 groups each of six rats. group-I (0.9% normal saline), group-II diphenylhydantoin (10 mg/kg/BW/ip), group-III carvedilol (1mg/kg/BW/PO), group-IV carvedilol (2 mg/kg/BW/PO) and group-V carvedilol (4 mg/kg/BW/PO). All the groups were administered drugs and subjected to electric shock. Scores of seizures and percentage of protection were recorded to compare between the groups. One was ANOVA (post hoc) followed by Dunnet t test applied to find the statistically significant between the groups.

Results: Group-I showed significant difference compared to other groups. Group-II showed significant difference with group-III and IV not with V. High dose of test drug and standard drug showed similar results in percentage of seizures prevention. Control and low doses of test drugs showed significant difference compared to standard and high dose of test drug in seizures prevention.

Conclusions: High of carvedilol showed significant seizures prevention compared to low doses and control group.

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