Evaluation of the effect of metformin on the inhibitory effect of oxytocin on potassium chloride stimulated goat ileum
Keywords:Oxytocin, Ileum, Glucose, Contractile, Potassium, Gut
The posterior pituitary hormone, oxytocin is expressed in the myenteric and submucous ganglia and nerve fibers along the entire human gastrointestinal (GI) tract. The role for oxytocin in the physiology and pathophysiology of the bowel remains to be clearly elucidated. Many studies have described that oxytocin exerts stimulatory or inhibitory effects on gut functions. Recently, mRNA for oxytocin and its receptor was found throughout the entire human GI tract. In this study, we examined the responses of the posterior pituitary hormone, oxytocin on the contractile responses to KCl and the effect of metformin on these responses as it affects the glucose transport and causes monoamine release in the gut.
Monstein HJ, Grahn N, Truedsson M, Ohlsson B. Oxytocin and oxytocin receptor mRNA expression in the human gastrointestinal tract: a polymerase chain reaction study. Regul Pept. 2004;119:39-44. [DOI via Crossref]
Tyagi MG, Kodagali R. Is oxytocin a key hormone for gene regulation and physiological function in postmenopausal women; an inquest into possible mechanisms? Ind Jr Appl Biol Pharma Tech. 2012;3(4):451-6.
Louvel D, Delvaux M, Felez A, Fiormonti J, Bueno L, Lazorthes Y, et al. Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome. Gut. 1996;39:741-7. [DOI via Crossref]
Levy B. The intestinal inhibitory response to oxytocin, vasopressin and bradykinin. J Pharmacol Exp Ther. 1963;140:356-66.
Wu CL, Hung CR, Chang FY, Pau KY, Wang PS. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:406-13. [DOI via Crossref]
Bailey CJ, Wilcock C, Scarpello JH. Metformin and the intestine. Diabetologia. 2008;51:1552-3. [DOI via Crossref]
Tembhurne SV, Sakarkar DM. Transport of glucose in isolated goat ileum preparation: an alternative research tool for absorption study. Indian J Physiol Pharmacol. 2008;52(2):211-3.
Science and plants for schools: Estimating glucose concentration in solution. (2007) SAPS.
Hashmonai M, Torem S, Argov S, Barzilai A, Schramek A. Prolonged post-vagotomy gastric atony treated by oxytocin. Br J Surg. 1979;66:550-1. [DOI via Crossref]
Petring OU. The effect of oxytocin on basal and pethidine induced delayed gastric emptying. Br J Clin Pharmacol. 1989;28:329-32. [DOI via Crossref]
Welch MG, Tamir H, Gross KJ, Chen J, Anwar M, Gershon MD. Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J Comp Neurol. 2009;512:256-70. [DOI via Crossref]
Cubeddu LX, Bonisch H, Gothert M, Molderings G, Racke K, Ramadori G, et al. Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000;361:85-91. [DOI via Crossref]