DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20203994

Acquaintance, approach and application of pharmacovigilance: questionnaire based study at a tertiary care teaching hospital in Dhaka

Morshed Nasir, Tahmina Zahan, Nadia Farha, A. S. M Salauddin Chowdhury

Abstract


Background: Pharmacovigilance is proven as an effective monitoring mechanism for safety and efficacy of pharmaceutical products with the assistance of physicians, pharmacists, nurses, and other healthcare professionals to avoid undue physical, mental and financial suffering of patients. Thus, this study was conducted to assess awareness of pharmacovigilance among the healthcare service providers to evaluate the acquaintance, approach application (3A) of judicial reporting of ADRs and pharmacovigilance in a tertiary care teaching hospital in Dhaka.

Methods: A pre-tested questionnaire-based study was done among the 5th year medical students, interns, doctors and nurses of Holy Family Red Crescent Medical College, Dhaka, Bangladesh to assess the overall status of acquaintance (knowledge), approach (attitude) and application (practice) pharmacovigilance. Total 417 questionnaires were distributed and 389 were included as valid, compiled and analysed using SPSS version 25.0.

Results: Among the respondents, almost 78% of the nurses responded the right answers and doctors responded the lowest 29% on average. The average percentage of approach and application of pharmacovigilance was low in all the respondent groups. The poorest outcome was observed about reporting an adverse drug reactions (ADR) form by all respondents as 01% to 08%.

Conclusions: The overall status of pharmacovigilance in a tertiary teaching hospital was found paradoxically low, that revealed the necessity of much more initiatives at the undergraduate and postgraduate academic curriculum and intensive motivation, training, monitoring should be addressed to ensure the safety of medication, rationality of drug use and accomplish the national pharmacovigilance programs.


Keywords


Pharmacovigilance, ADR, Rational drug use, Drug safety, ADR reporting

Full Text:

PDF

References


World Health Organization. Committee of Experts on Management of Safety and Quality in Health Care (SP SQS) Expert Group on Safe Medication Practices. Glossary of Terms Related to Patient and Medication Safety: World Health Organization; Available at: https://www.who.int/patientsafety/

highlights/COE_patient_and_medication_safety_gl.pdf. 2005;13.

Thangaraju P, Venkatesan S, Tamilselvan T, Sivashanmugam E, Showkath Ali MK. Evaluation of awareness about pharmacovigilance and adverse drug reaction monitoring among medical professionals attending Central Leprosy Institute. Mustansiriya Med J. 2018;17:63-8.

World Health Organization. The importance of pharmacovigilance. 2002. Accessed in: https://apps.who.int/iris/bitstream/handle/10665/42493/a75646.pdf. Accessed on 20/08/2020.

Datta S, Sengupta S. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting in a tertiary care teaching hospital of Sikkim. Perspectives in clinical research. 2015;6(4):200-6.

World Health Organization. The Safety of Medicines in Public Health Programmes Pharmacovigilance an Essential Tool. Geneva: World Health Organization; 2006. Available from: http:// www.who.int/medicines/areas/quality_safety/safety_efficacy/ Pharmacovigilance_B.pdf. Accessed on 20/08/2020.

Ajoy B, Bezbaruah B, Swapnanil G. Knowledge, Attitude and Practices of Pharmacovigilance among junior doctors of a tertiary health care institute in North East India. J Appl Med Sci. 2016;4(9A):3248-53.

Meyboom RHB, Hekster YA, Egberts ACG, Gribnau FWJ, Edwards IR. Casual or Causal? The role of causality assessment in pharmacovigilance. Drug Safety. 1997;16:374-89

Craven BM, Stewart GT, Khan M. Chan TYK. Monitoring the safety of herbal medicines. Drug Safety. 1997;17(4):209-15.

Dharman D, Krishnan P, Ravikumar KG, Dharan SS, Rajan S. The era of pharmacovigilance and the need of pharmacovigilance in psychiatry: A review. J Drug Delive Therap. 2019; 9(1):449-52.

Central Drugs Standard Control Organization. Long Term Objective of Pharmacovigilance Programme in India. Available from: http://www.cdsco.nic.in/

pharmacovigilance_intro.htm. Accessed on 20/08/2020.

Md Al-Mustansir, Saha D, Paul S, Rahim ZB, Hosen SMZ. Studies on Pharmacovigilance in Bangladesh: Safety Issues. IJPTP. 2013;4(2):613-21.

Karelia BN, Piparava KG; Knowledge, attitude and practice of pharmacovigilance among private healthcare professionals of Rajkot city. Int J Basic Clin Pharmacol, 2014;3:50-3.

Hardeep, Bajaj JK, Rakesh K. A Survey on the Knowledge, Attitude and the Practice of Pharmacovigilance Among the Health Care Professionals in a Teaching Hospital in Northern India. J Clin Diagn Researc. 2013;7:97-9.

Pimpalkhute SA, Jaiswal KM, Sontakke SD, Bajait CS, Gaikwad A. Evaluation of awareness about pharmacovigilance and adverse drug reaction monitoring in resident doctors of a tertiary care teaching hospital. Indian J Med Sci. 2012;66(3-4):55-61.

Gupta SK, Nayak RP, Shivaranjani R, Vidyarthi SK. A questionnaire study on the knowledge, attitude and practice of pharmacovigilance among the healthcare professionals in a teaching hospital in South India. Perspect Clin Research. 2015;6(1):45-52.

Hema NG, Bhuvana KB. Pharmacovigilance: the extent of awareness among the final year students, interns and postgraduates in a government teaching hospital Sangeetha. J Clin Diag Res. 2012;6(7):1248-53.

Dikshit RK, Desai C, Desai MK. Pleasures and pains of running a pharmacovigilance center. Indian J Pharmacol. 2008;40(1):S31-4.

Bepari A, Niazi SK, Rahman I, Dervesh AM. The comparative evaluation of knowledge, attitude, and practice of different health-care professionals about the pharmacovigilance system of India. J Adv Pharmac Technol Res. 2019;10(2):68-74.

Tabali M, Jeschke E, Bockelbrick A, Witt MC, Willich SN, Ostermann T et al. Educational intervention to improve physician reporting of adverse drug reactions (ADRs) in a primary care setting in complementary and alternative medicine. BMC Public Health 2009;9:274.