Malaria related myalgia-arthralgia: an imported case report treated with anti-malarial drug
Keywords:Imported malaria, Febrile, Fever, Muscle, Pain, Combotherapy
Malaria is still a major health problem in Indonesia, especially in endemic areas. We present an imported case of malaria with prominent subjective complaint of the patient is in the form of persistent muscles and joints pain. A 21 years old female with complaint of intermittent fever and persistent muscle joints paint since one week before seeing a doctor. She had history of repetitive attack of malaria tropica. Physical examination in general showed no clear derangements, but on thick and thin blood smear stained with Giemsa revealed malaria falciparum (+). Combo therapy of antimalarial drug soon be given and the patient healed with the disappearance of all previous complaint. Myalgia and arthralgia in case of malaria falciparum (+) might be the earliest subjective sign of rhabdomyolisis, a potentially fatal and lethal complication of malaria.
Antinori S, Galimberti L, Milazzo L, Corbellino M. Biology of Human Malaria Plasmodia Including Plasmodium Knowlesi. Medite J Hemato Infec Dise. 2012;4:e2012013.
Talapko J, Škrlec I, Alebić T, Jukić M, Včev A. Malaria: The Past and the Present. Microorganisms. 2019;7(6):179.
Sitohang V, Sariwati E, Fajariyani B, et al. Malaria elimination in Indonesia: halfway there. Lancet Glob Health. 2018;6(6):604-6.
Tizifa A, Kabaghe N, McCann S, van den Berg H, Van Vugt M, Phiri KS. Prevention Efforts for Malaria. Curr Trop Med Rep. 2018;5(1):41-50.
Lederman E, Sutanto I, Wibudi A, Ratulangie L, Rudiansyah I, et al. Imported Malaria in Jakarta, Indonesia: Passive Surveillance of Returned Travelers and Military Members Postdeployment. J travel med. 2006;13:153-60.
Reynaud F, Mallet L, Lyon A, Rodolfo M. Rhabdomyolysis and acute renal failure in Plasmodium falciparum malaria. Nephro Dialysis Transplant. 2005;20(4):847.
Marrelli M, Brotto M. The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles. Malaria J. 2016;15.
Siqueira M, Alexandre A, Mourão P, Santos S, Nagahashi K, Alecrim G, Lacerda V. Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon. J Trop Med Hyg. 2010;83(2):271-3.
Nance R, Mammen L. Diagnostic evaluation of rhabdomyolysis. Muscle Nerve. 2015;51(6):793-810.
Marrelli T, Wang Z, Huang J, Brotto M. The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression. Malar J. 2020;14;19(1):254.
Boni F, White J, Baird K. The Community As the Patient in Malaria-Endemic Areas: Preempting Drug Resistance with Multiple First-Line Therapies. Plos Med. 2016;13(3):e1001984.