Drug prescribing pattern in patients of myocardial infarction in a tertiary care teaching hospital of North India

Akanksha Mehra, Nusrat K. Bhat, Sushil K. Sharma, Kanika Khajuria


Background: The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Aims of this study were to assess drug prescribing pattern in patients of myocardial infarction and to compare prevalence of MI according to age, gender, diet, smoker or non-smoker, alcoholic or non-alcoholic, family history of cardiovascular disease.

Methods: This observational study was conducted at department of pharmacology, in association with department of cardiology and included all patients of myocardial infarction visiting cardiology outpatient department or indoor patients and proforma was used to evaluate drug prescribing pattern.

Results: Total 200 patients of acute myocardial infarction were analysed. Incidence of MI was more common in males (76%); age group 51-60 years (28.5%); non-vegetarians (68.5%); smokers (52.5%) and reduced physical activity (70.5%). 59.5% of patients had family history of cardiovascular disease. Commonly prescribed drugs were antiplatelets (100%) followed by hypolipidemic (99.5%), proton pump inhibitors (92%), antianginal (90.5%), anticoagulants (68.5%), thrombolytics (24.5%).

Conclusions: This study provides insight towards drug prescribing pattern in MI patients. Most frequently prescribed drugs were antiplatelets followed by hypolipidemic and proton pump inhibitors. Patients had multiple risk factors and these can be reduced by lifestyle modifications.


Myocardial infarction, Prescribing pattern, Drugs, Cardiovascular disease, Aspirin

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Gaziano TA, Gaziano JM. Epidemiology of cardiovascular disease. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 19th ed. New York, NY: McGraw Hill; 2016: 266e1-266e5.

World Health Organization. Global Status Report on Non-Communicable Diseases 2014. Available at: Accessed on June 2020.

Anand IS, Chhabra ST. Ischemic Heart Disease. In: Munjal YP, Sharma SK, Agarwal AK, Gupta P, Kamath S, Nadkar MY, Singal RK, Sundar S, Varma S, eds. API Textbook of Medicine. 9th ed. Mumbai; 2012: 666-672.

Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Rohani AH, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224-60.

Gupta R, Mohan I, Narula J. Trends in Coronary Heart Disease Epidemiology in India. Ann Glob Health. 2016;82(2):307-15.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the inter heart study): case-control study. Lancet. 2004;364(9438):937-52.

Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: A mechanism for arterial thrombosis and myocardial infarction. Circulation. 1999;99:1411-5.

Mitchell RN. The Heart. In: Kumar V, Abbas AK, Aster JC, eds. Robbins Basic Pathology. 8th ed. Elsevier; 2013: 365-406.

Chaudhari P, Agrawal JM, Malhotra SD, Patel VJ. Drug utilization pattern in acute coronary syndrome at tertiary care hospital: a prospective cross-sectional observational study. Int J Basic Clin Pharmacol. 2016;5(2):513-16.

Deshmukh S, Deshpande A, Kulkarni ND. Clinical profile of Acute Myocardial Infarction patients from Rural India. JMSCR. 2017;5(11):30106-11.

Ghosh A, Das AK, Pramanik S, Saha UK. Drug utilization study in patients of Acute Coronary Syndrome on follow-up visits at a Tertiary Care Centre in Kolkata. Asian J Pharm Life Sci. 2012;2(2):155-65.

Pandey S, Pandey S, Jhanwar P, Jhanwar A. A prospective study of Myocardial Infarction patients admitted in a tertiary care hospital of south-eastern Rajasthan. Int J Biol Med Res. 2012;3(2):1694-96.

Gan SC, Beaver SK, Houck PM, MacLehose RF, Lawson HW, Chan L. Treatment of Acute Myocardial Infarction and 30 days Mortality among Women and Men. N Engl J Med. 2000;343(1):8-15.

George J, Devi P, Kamath DY, Anthony N, Kunnoor NS, Sanil SS. Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital. J Cardiovasc Dis Res. 2013;4(4):214-21.

Vakade KP, Thorat VM, Khanwelkar CC, Jadhav SA, Sanghishetti VM. A study of prescribing pattern of drugs in patients of cardiovascular emergencies at a tertiary care hospital of Western Maharashtra. Int J Res Med Sci. 2016;4(2):556-61.

Pendhari SR, Chaudhari DR, Burute SR, Bite BM. A study on the drug utilization trends in the cardiovascular emergencies in a tertiary care hospital. J Clin Diagn Res. 2013;7(4):666-70.

Patel R, Jawaid T, Shukla PK, Singh MP. Evaluation of Drug utilization pattern in patient of Myocardial Infarction and Prevalence of the MI by comparison of Age, Sex, Diet, Smokers and Non-smokers, Alcoholic and Non-alcoholic. Am J Pharmacol Pharmacother. 2015;2(1):72-80.

Nagabushan H, Roopadevi HS, Prakash GM, Pankaja R. A prospective study of drug utilization pattern in cardiac intensive care unit at a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2015;4(3):579-83.

Association of Physicians of India. API expert consensus document on management of ischemic heart disease. J Assoc Physicians India. 2006;54:469-80.

Tanna PJ, Hotha PP, Thakkar SC. A study on prescribing pattern of drugs prescribed in patients of acute myocardial infarction admitted in ICCU at a tertiary care hospital. Int J Res Pharmacol Pharmacother. 2019;8(1):97-104.

Vyas A, Ahamed J, Batar KK, Gehlot A. To study Prescription pattern of drugs and other prophylactic measurements for survivors of acute myocardial infarction at tertiary care teaching hospital, western Rajasthan. Int J Sci Res. 2019;8(7):9-11.

Jewargi PKB, Mala RD. Drug utilization study in Congestive Heart Failure at a Tertiary Care Hospital. Sch J App Med Sci. 2015;3(2):857-62.