Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models


  • Anthony U. Megwas Department of Optometry, School of Health Technology, Federal University of Technology, Owerri, Nigeria
  • Godwin C. Akuodor Department of Pharmacology and Therapeutics, College of Health Sciences, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
  • Leo C. Chukwu College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Amaku, Awka, Nigeria
  • Daniel O. Aja Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
  • Edmund M. Okorie Department of Optometry, School of Health Technology, Federal University of Technology, Owerri, Nigeria
  • Elochukwu C. Ogbuagu Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Nigeria
  • Desmond O. Eke Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
  • Anuli N. Chukwumobi Department of Internal Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Nigeria



Anonna senegalensis, Analgesic, Anti-inflammatory, Antipyretic


Background: This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals.

Methods: The analgesic activity was measured using the abdominal constriction and tail flick tests. The anti-inflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively.

Results: The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities.

Conclusions: Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.


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How to Cite

Megwas, A. U., Akuodor, G. C., Chukwu, L. C., Aja, D. O., Okorie, E. M., Ogbuagu, E. C., Eke, D. O., & Chukwumobi, A. N. (2020). Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models. International Journal of Basic & Clinical Pharmacology, 9(10), 1477–1484.



Original Research Articles