Comparative study of assay of free radical damage in in vivo, in vitro and ex vivo conditions

Authors

  • Amit Singh Department Pharmacology,Institute of Medical Sciences,Banaras Hindu University,Varanasi - 221 005,Uttar Pradesh,India
  • Surendra Pratap Mishra Department of Biochemistry,Institute of Medical Sciences,Banaras Hindu University,Varanasi - 221 005,Uttar Pradesh,India
  • Abha Mishra School of BiochemicalEngineering, Indian Institute of Technology, Banaras Hindu University, Varanasi - 221 005,Uttar Pradesh, India

Keywords:

Antioxidant, Ginkgobiloba, Malondialdehyde

Abstract

Background: Interception of free radical events and damage in clinical situation remain arbitrary with poor understanding on antioxidant pharmacology. Methods: Experiments on in vitro per-oxidation insult as well as assumed free radical damage situation in ischemia reperfusion are examined for profile of malondialdehyde rise and effect of Gikgobiloba treatment by different schedule.

Results: Effect of Ginkgobiloba was seen on ischemia reperfusion induced, hydrogen peroxide induced and ferric chloride induced methods. Antioxidant effect of Ginkgobiloba was consistent in all techniques.

Conclusions: Results reveal the significance of complementary experiment to elaborate issue of antioxidants.

References

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Published

2017-01-02

How to Cite

Singh, A., Mishra, S. P., & Mishra, A. (2017). Comparative study of assay of free radical damage in in vivo, in vitro and ex vivo conditions. International Journal of Basic & Clinical Pharmacology, 3(2), 308–314. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/427

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Section

Original Research Articles