Tigecycline: pharmacological concerns and resistance


  • Rama Paudel School of Biomedical Sciences, Trinity Medical Sciences University, Kingstown, St. Vincent and the Grenadines, West Indies
  • Hari P. Nepal School of Medicine, Trinity Medical Sciences University, Kingstown, St. Vincent and the Grenadines, West Indies




Tigecycline, Multidrug resistant bacteria, Resistance


Tigecycline, a semisynthetic derivative of minocycline, has a broad spectrum of activity against both gram positive and gram negative multidrug resistant bacteria.  The drug acts on 30S ribosomal subunit and inhibits protein synthesis. Since the drug has excellent tissue distribution, it is very useful for treatment of skin infections, intra-abdominal infections and pneumonia. Side effects of the drug are usually mild. The common side effects include nausea and vomiting. The exact mechanism of resistance remains unclear. However, resistance mediated by enhanced expression of resistance nodulation cell division (RND) type efflux pumps is one of the most frequently reported mechanisms. Resistance has been observed worldwide. However, the rate of resistance is low.

Author Biography

Rama Paudel, School of Biomedical Sciences, Trinity Medical Sciences University, Kingstown, St. Vincent and the Grenadines, West Indies

Assistant Professor, Department of Biology


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How to Cite

Paudel, R., & Nepal, H. P. (2020). Tigecycline: pharmacological concerns and resistance. International Journal of Basic & Clinical Pharmacology, 9(8), 1296–1300. https://doi.org/10.18203/2319-2003.ijbcp20203151



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