Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20203534Keywords:
Drug utilization, Chemotherapy, Metastatic cancer, Antibiotic, Adjuvant drugsAbstract
Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs.
Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.
Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.
Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed.
References
Mallath MK, Taylor DG, Badwe RA. The growing of cancer in India: epidemiology and social context. Lancet Oncol. 2014;15:205-12.
Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends: An Update. Cancer Epidimiol Biomarkers Prev. 2007;25(1):16-27.
Global Cancer Observatory (GCO). Available at: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed on 13 July 2018.
Pentareddy MR, Suresh AVS, Shailendra D. Prescription pattern of anticancer drugs in a tertiary care hospital. J Evidence Based Med Healthcare. 2015;2(20):3001-9.
Damodar G, Gopinath S, Vijayakumar S. Reasons for Low Quality of Life in South Indian Cancer Patient Population: A Prospective Observational Study. Indian J Pharm Sci. 2014;76(1):2-9.
Kondra RR, Ghongane BB. Drug utilization research: need of the hour. Int J Pharm Bio Sci. 2013;4(3):170-8.
Kumari R, Kaur J, Kajal M. A Review on Quality of Life in Cancer Patients: An Indian Scenario. Int J Cur Res Rev. 2017;9(15):722-4.
Demir A. Factors affecting the quality of life of cancer patients undergoing chemotherapy: A questionnaire study. Asia Pacific J Oncology Nursing. 2015;2(1):17-25.
Mugada VK, Paruchuri A, Munagala M. Drug Utilization Evaluation of Anticancer Drugs in a Tertiary Care Teaching Hospital: an observational study. J Applied Pharmaceutical Sci. 2016;6(10):98-101.
Yeo W, Frankie KFM. Quality of life of young Chinese breast cancer patients after adjuvant chemotherapy. Cancer Management Res. 2018;10:383-9.
Rosati G, Pinto C. Quality of life, compliance, safety and Effectiveness in fit older metastatic colorectal patients with cancer treated in first line with chemotherapy plus cetuximab: a retrospective analysis from the observer study. J Geriatric Oncology. 2018;9:243-8.
Shalini S, Ravichandran V, Mohanty BK. Drug Utilization Studies: An Overview. Int J Pharmaceutical Sci Nanotechnology. 2010;3(1):1-3.
Varghese ST. A Prospective Observational Study on Drug Utilization Pattern of Restricted Antibiotics: Colistin, Teicoplanin and Tigecycline in 59 Tertiary Care Hospital. Indian J Pharmacy Practice. 2017;10(3):216-21.
Kulkarni MD. Drug utilization review of anticancer drugs in cancer outpatient department of the Government Medical College, Aurangabad. Int J Basic Clin Pharmacol. 2014;3(5):879-83.
Siddiqua A, Jafar H, Tabassum N. Drug Utilization Evaluation of Anti-Cancer Drugs. Am J Pharm Tech Res. 2014;4(3):691-702.
Dave DJ, Pillai A, Shah DV, Agarwal S, Goel A. An analysis of utilization pattern of anticancer drugs in diagnosed cases of carcinoma in a tertiary care teaching hospital. Int J Basic Appl Med Sci. 2014;4:251-9.
